19 days agoBarcelona coach Valverde admits Dembele dismissal baffled him

first_imgBarcelona coach Valverde admits Dembele dismissal baffled himby Carlos Volcano19 days agoSend to a friendShare the loveBarcelona coach Ernesto Valverde admits Ousmane Dembele’s dismissal against Sevilla baffled him.Dembele was sent off late in Barcelona’s win for comments made to the referee just moments after Ronald Araujo was shown a straight red himself.It has been reported that the Frenchman said “very bad, you’re very bad” to the referee, which saw him given his marching orders.”I don’t know what he said,” Valverde said when asked for his opinion in his post-match press conference.”But I don’t think it was too long a sentence.”With the Araujo dismissal on his debut, it didn’t seem like a foul to me.”Then the Dembele one is a mystery.”Looking at the match as a whole, Valverde was understandably delighted to finish with such a comprehensive scoreline.”It was a complicated and important game for us,” he explained.”They’ve had a lot of chances, but this is what it is.”They left spaces and we had more punch, which proved key.” About the authorCarlos VolcanoShare the loveHave your saylast_img read more


Oklahoma’s Jamal Danley Shares 1-Year-Old Facebook Post From Fan Telling Him Not To Play For Sooners

first_imgJamal Danley's Facebook post 1 year later.jamal danley facebook postIn 2014, Oklahoma posted an 8-5 record, finished fourth in the Big 12, and got blasted by Clemson in the Russell Athletic Bowl, 40-6. In the offseason, the Sooners made a number of coaching changes – especially on the offensive side of the ball – in an attempt to reestablish dominance in the conference. A year later, they’re 11-1 and a lock to make the College Football Playoff.Tuesday, junior offensive lineman Jamal Danley, who was a four-star JUCO transfer this year, posted a Facebook message that was written to him while he was making his decision on where to play in 2015. The post, which looks to have been sent by a fan, focuses on Oklahoma’s demise and calls Danley “SEC material.” Danley clearly finds it amusing, seeing where OU is right now.1 year later! pic.twitter.com/Z9HiJrX8NG— Jamal Danley™ (@JDanley54) November 30, 2015Oklahoma has off this week as it prepares for to play for a national championship. Apparently, not everyone saw that coming a year ago.last_img read more


Freshmans late goal lifts Ohio State womens soccer team into Sweet 16

OSU junior forward Nichelle Prince (7)during a game against Butler in the opening round of the NCAA tournament on Nov. 14 at Jesse Owens Memorial Stadium. OSU won 2-1. Credit: Courtesy of OSUThe Ohio State women’s soccer team (13-6-3) is headed to the Sweet 16 after defeating the Virginia Tech Hokies (15-4-2) on Friday afternoon 1-0 in the second round of the NCAA tournament. Freshman midfielder Arden Holden netted her first career goal with 11 minutes remaining to keep the Buckeyes’ postseason run afloat. With the win, the Scarlet and Gray are headed to their third Sweet 16 in the past six seasons. The beginning of the game was slow, as the first 15 minutes did not present many opportunities to score for either side. In the 20th minute, OSU finally got to a solid opportunity in the final third when senior midfielder/forward Michela Paradiso tried to curl one in from 20 yards out on the left wing but it sailed over the crossbar. Two minutes later, the Buckeyes had another opportunity to score when junior forward Lindsay Agnew sent a strong ball to junior forward Nichelle Prince, but a Virginia Tech defender cleared it away. The Hokies, who entered the game as the 14th-overall seed, were able to generate a scoring opportunity in the 43rd minute when sophomore forward Alani Johnson sent one on the frame, but OSU redshirt junior goalkeeper Jillian McVicker made a lunging save to preserve the scoreless match. The teams headed into the locker rooms at halftime tied 0-0. The Hokies led the Buckeyes 6-1 in shots, 1-0 on goal. OSU came back in the second half with plenty of opportunities to score early on, but the Buckeyes simply could not find the back of the net. In the 79th minute, the Buckeyes put the one and only goal on the board. Prince split two Virginia Tech defenders before playing the ball out to Holden who finished off the keeper. Holden has appeared in 21 of the Buckeyes’ 22 games this season, but her game-winning goal marked the first time in her young career she has scored. The final 11 minutes of play contained some opportunities for the Hokies to level the match, including a solid look off a free kick in the 87th minute, but they could not get past McVicker, meaning OSU was able to hold on for the 1-0 win. For the game, Virginia Tech held a sizable lead in shots, 20-5, including 4-2 on goal. McVicker made four saves to earn her second clean sheet of the season for OSU. The Buckeyes are set to play conference foe Penn State in the Sweet 16 after the Nittany Lions dominated Boston University in the second round, winning 6-0. In the lone meeting between the two teams during the regular season, Penn State topped OSU 2-1 on Oct. 24. With an opportunity to advance to the quarterfinals on the line, the rematch is set to take place on Sunday in State College, Pennsylvania.  Kickoff is penciled in for 1 p.m. read more


Football Notebook Changing season changing role players for the Buckeyes

Replacing Chris “Beanie” WellsOne question in everyone’s mind going into this season was how the Buckeyes were going to make up for losing one of the strongest running backs in college football, “Beanie” Wells. But, in their season opener against Navy, two backs paired up for quite the punch against the midshipmen defense. Dan Herron and Brandon Saine combined for 125 rushing yards. Herron had 17 carries for 72 yards and a touchdown. Saine averaged 5.9 yards on nine carries with a 14-yard carry in the second quarter while backup quarterback Joe Bauserman struggled to make a drive. Just two plays later, Saine connected with Bauserman for 13 yards and then carried the ball two more yards for a first down. “It felt really good you know,” Saine said. “I felt like I did what I needed to do out there. I might not have been able to score a touchdown or anything, but I feel like I contributed.” Defense struggles early, but finishes strongEarly on in the game, it looked as if the Buckeye defense was struggling to control the unique Navy offense. On their first possession, Navy had a seven-minute drive that consisted of 15 plays mostly on the ground for 80 yards and a 16-yard touchdown run by quarterback Ricky Dobbs. “We knew coming into this game that they were going to be a lot faster and we felt we needed to execute that first series so we were a little disappointed coming off the field after that first series knowing we had to step it up,” said Kurt Coleman, senior safety and OSU captain. But, it was the defense that eventually saved the day, stopping a two-point conversion with minutes left in the game, when Brian Rolle intercepted a pass from Dobbs and ran it back gaining two points for the Buckeyes. Captains excel and lead in openerThe three defensive captains combined for 13 tackles in the opener against Navy. Coleman forced a fumble in the fourth quarter when Navy was on second down with seven yards to go. Fellow captain, senior defensive lineman Doug Worthington was able to recover that fumble and the two set the offense up for a touchdown drive to put the Buckeyes up 29-14. Duron Carter makes a dazzling debut True freshman wide receiver Duron Carter, son of OSU alum Cris Carter, made his debut as a Buckeye yesterday. Carter played most of the game after sophomore DeVier Posey left with a minor ankle injury. Carter ranked third in the receiving stats for Ohio State with three receptions for 21 yards. “Little Carter was great. He caught a lot of balls and he looked awesome out there as well as a lot of other guys,” Worthington said of the young player. “I’m proud of a lot of guys stepping up, they looked great.” Carter said that he felt really comfortable on the big stage in front of a record of 105,092 fans on opening day. “It feels great. A lot of freshman receivers have started out their career great and hopefully I can be the next one and just step up during the on-coming weeks,” Carter said. Ohio State still having trouble closing in the red zone The Navy defense forced the Buckeyes to settle for a field goal on three separate occasions in the first, second and fourth quarters. And there probably should have been a fourth when instead of kicking, Tressel decided to go for it on fourth-and-one on the 15-yard line late in the fourth quarter. Despite Aaron Pettrey’s success, making good on a 23-yard, 25-yard and 52-yard field goal, it makes one wonder why they couldn’t push the ball into the end zone on four different occasions. “Those are the ones we had trouble with a year ago, the ones that started between the eight and the 10, so do you leave a little disappointed?” coach Jim Tressel asked himself. “Yeah, because you want to score touchdowns.” Ohio State didn’t exactly deliver what everyone had hoped they would in the season opener against Navy, in which they pulled off a shaky 31-27 victory over the Midshipmen. With a lot of young and inexperienced players stepping into the starting roles this season, it was uncertain who would make an impact, and how they would make an impact. With yesterday’s game against Navy under their belts, the Buckeyes cleared the fog a little as to who will be making headlines this season. read more


India UK launch clean air initiative in Bengaluru

first_imgWomen and children are at greater risk than men.ReutersThe Innovation for Clean Air (IfCA) was launched in Bengaluru on Wednesday. The two-year UK-India joint initiative provides Indian and UK stakeholders opportunities to test interventions related to air quality and EV integration. Speaking at the IfCA launch on Wednesday, British Deputy High Commissioner Dominic McAllister said: “I am delighted to launch this joint programme. Such collaborative initiatives are an example of how the UK and India can work as a joint force for good on innovative solutions and can bring the best of our research communities, academia and businesses together to address shared challenges, such as clean air.”The initiative provides a unique measurement system for air quality by integrating satellite and sensor data and helping to support India’s transition to electric vehicles. The programme is led by Innovate UK, part of UK Research and Innovation (UKRI), and is funded by the Newton Fund with matched resources from various partners in Karnataka and India. Speaking at the IfCA launch, British Deputy High Commissioner Dominic McAllister said: “The UK and India can work as a joint force to bring the best of our research communities, academia and businesses together to address shared challenges, such as clean air.”UK Research and Innovation India (UKRI) Director Rebecca Fairbairn said: “This is a really exciting initiative. UKRI has been working with India for over a decade, focussing on excellent research that makes a difference to society and to our economies but this is the first time the UK Catapult network, which drives innovation in highly targeted industries has been implemented here and it demonstrates the creativity possible through India-UK partnership.”The key partners for the programme are the Indian Institute of Science (IISc), Enzen, Project Lithium, Confederation of Indian Industries, C40 Cities and Clean Air Platform. Other partners include Citizens for Sustainability, World Resources Institute, Indian Institute for Information Technology Bangalore (IIIT-B), Shakti Foundation, Shell Technology Centre, Global Business Inroads and India Smart Grid Forum. A current UK partner is Earthsense working in collaboration with the Catapults.Air quality & EV innovation: Bengaluru and London share challenges and opportunities in relation to improving air quality. The two cities are founding partners of the C40 Air Quality Network. The programme will identify innovations that have the potential to improve air quality and provide an environment to test and refine ideas. In parallel, the programme will contribute to a more detailed localised map of the air quality of Bengaluru through the unique combination of satellite and sensor data, including both on-the-ground and mobile data. The programme will identify relevant challenges around EV charging infrastructure, grid management and integrating renewable energy to ensure a sufficient, reliable and clean source power and facilitate opportunities for Indian and UK innovators to collaborate in developing long-lasting relationships to address these challenges.Innovate UK is funding the UK Catapult network in executing this programme. The UK Catapults network established by the UK government is a network of world-leading organisations focused on driving innovation in specific industrial sectors. They bring together the best businesses, scientists and engineers to work side by side on late-stage research and development. Representatives from the UK Energy Systems, Connected Places and Satellite Applications Catapults are in Bengaluru, Karnataka this week to launch the UK-India Innovating for Clean Air programme. They met stakeholders in Bengaluru, including the state government. Due to the enthusiasm of stakeholders such as the success of Lithium Taxis and BMTC’s plan to launch electric buses, the Catapult network has decided to focus on Bengaluru to enhance the progress already made in air quality and electric vehicle transition in Bengaluru.last_img read more


Atascocita Student Arrested After Taking Saw Blade To School Having Hit List

first_img Share A Humble ISD student was arrested this week after he took an 8-inch saw blade to Atascocita Middle School. An investigation also found he had a hit list with the names of some students.Karl Koehler, the school’s principal, sent a letter to parents on Wednesday saying the Humble ISD Police Department conducted an investigation and gathered information for the Harris County District Attorney’s Office. According to the letter, the saw the student took to school is the type of tool used to cut tree branches.“All students are safe. Our school administration is having personal conversations with the parents of students whose names were listed,” the letter read.The district attorney’s office has filed a charge of possession of a prohibited weapon, a third degree felony.last_img read more


Three small steps to zero hunger

first_imgHow many times has it happened that you ordered too much food and left it unfinished? Many times, I guess. Food wastage is a universal problem and even after much has been said and done about it, many countries have failed to control it. And India is getting worse than ever. Among 118 developing countries, India ranked 97, in the Global Hunger Index (GHI) 2016. This data is sufficient enough to show how serious the condition is.While we grapple with the crisis of food wastage, three class 11th girls, have already taken small little steps to minimise this wastage. Vandita Bhartiya, Rhea Kapuria, and Ikshita Puri strongly believe in the words of Mother Teresa – “If you can’t feed a hundred people, then feed just one.” Their journey towards zero hunger began when the three girls went to a restaurant in Greater Kailash 1 for a light snack. “When we couldn’t finish what we ordered in that restaurant and saw the amount of food we wasted, it hit us really hard. Here we are sitting in an air conditioned restaurant, wasting food, and outside, dozens of people are begging to have a single meal. We just thought of the fact that we could have given the leftover food to these people instead of throwing it away.” Also Read – Add new books to your shelfTo make a point clear, when you order something, whatever is left on your plate is thrown away but the food in serving bowls can be used again. It is not always that the people order more and don’t finish, sometimes the restaurants also serve more than sufficient.These girls made it their business to know about the amount of food wasted and what is being done to it. “We spoke to the managers of several restaurants and found out about the wasted food. In most of the restaurants, the leftover food was consumed by their staff but even after that, much of it was thrown away because the food gets contaminated,” explained Ikshita. They reached out to over 50 restaurants, out of which only a handful agreed to help their cause. “In the beginning of our endeavour, we also approached a bakery and they agreed to help us. But we couldn’t accept their offer because we don’t have a cold storage vehicle to take it from one place to another,” sighed Vandita. Also Read – Over 2 hours screen time daily will make your kids impulsiveCurrently, these students have come to an understanding with only two restaurants to take leftover food – one in Saket and the other in Greater Kailash – and one whole slum area known as Sudhar Camp slum in Kalkaji, with approximately 500 people to feed. They have a single vehicle to go back and forth with oodles of food with a deadline to deliver it on the same day to avoid contamination in the sweltering heat. “We have kind of adopted that area in Kalkaji,” said Ikshita as the two of them agreed with her. Many restaurants don’t want to get associated with a novice, even if their intentions are good. In this case, the food might get contaminated; making a person sick and the restaurants will be blamed ultimately.For the future, the trio plans to deliver food to nearby slum areas of the restaurant they get food from but the current situation demands some more restaurants in the Kalkaji area to help them in their cause. “We picked up this slum purposely because traveling can damage the food. The restaurants that we have are in Saket and GK, so we send one car to Saket and the other (if we get one from any of our friends) to GK and then deliver the food to that area in Kalkaji. The slum looks small from the outside but if you go into the lanes, you will realize that just two restaurants are not enough to fulfill their needs,” said Ikshita.Even though they have scant resources and time, these girls are determined to fulfill the needs of this slum area. “We want that if we are covering an area then we do it properly, there should be no cutbacks on food. So right now our focus is that particular area in Kalkaji,” said Vandita.”We do this work on weekends and we inform the restaurants beforehand. Now the restaurants are attached to us so they also call us. And in the slum area also we have a person who we call up and tell them that we will be getting food for the day,” added Ikshita. While constantly thinking about how to get more and more restaurants to cooperate with them, Ikshita said, “Our steps are small but even if we reach 20-25 people, we will be satisfied because it’s for a good cause.” Zero Hunger by these students is just a small dent in a bigger problem but with support from people and restaurants, they can make a huge difference in the lives of thousands of people.last_img read more

Orange and Canal could collaborate to acquire pre

first_imgOrange and Canal+ could collaborate to acquire premium sports rights in the face of growing competition from SFR as part of a growing alignment of the pair’s interests, according to a report in French financial daily Les Echos.Citing an unnamed source, Les Echos reported that Orange and Canal+ were in discussion around how it could help Canal+ acquire premium rights, including financially.Rights to Formula 1 motor-racing and Champions League football are already in play, with rights to French domestic top-tier football up for auction in 2019. Altice and SFR have already indicated their interest in acquiring any available sports rights that could help it build its business.According to Les Echos, Orange would want to participate in Canal+ in a deeper way for any deal to make sense. One idea floated is the creation of a new company to commercialise Canal+ in France, in which Orange would be a majority shareholder. The pair could separately align their interests in Africa and Poland, where both are present.However, Les Echos points, out, there are major hurdles in the way of any deal between the groups. The French state’s interest in Orange could prevent any deal that allows the entry of Vivendi into the group’s ownership, while there could be regulatory concerns about the impact of a deal on rival fixed-line operators.The paper said that Orange CEO Stéphane Richard told employees at the end of last month that Orange was capable of acquiring Canal+ without giving a stake to Vivendi, but that it did not have this project in mind.last_img read more

The Great Wall of China A walk on the moon Genom

first_imgThe Great Wall of China. A walk on the moon. Genome sequencing. How did we humans, who share almost all of our DNA with chimpanzees, end up doing all that, while they ended up pretty much where they started?Some scientists will tell you it was language, or tools, or brainpower.Another group of researchers has come up with a new and surprising theory — that something else put us on the road to success. They say it has to do with how we raised our kids.This new theory claims that sharing — first of food and child care, then later of feelings and intentions — was the original secret of our species’ success. Without it, we might have occasionally hunted in a group like other apes, but human civilization requires more than occasional male bonding.So why did we evolve this ability to be so ultrasocial and ultrasharing? Why not chimps?See what these scientists think may have happened. Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

Disabled activists have welcomed the decision of d

first_imgDisabled activists have welcomed the decision of doctors to vote strongly against relaxing their union’s position on physician-assisted suicide.The British Medical Association (BMA) voted by 63 per cent to 37 per cent this week at its annual representative meeting (ARM) in Belfast to maintain its current position of being opposed to physician-assisted suicide.Some doctors had wanted the BMA to move to a neutral stance on the issue.Last September, the latest parliamentary attempt to weaken the law, through a private members’ bill put forward by Labour MP Rob Marris, was defeated by 330 votes to 118.But there were concerns after his bill was thrown out that pro-assisted suicide campaigners were already plotting their next move to try to force through legalisation, either through the courts or parliament.A move to a neutral position by the BMA would have given euthanasia supporters a significant boost in their continuing quest to change the law.Minutes before the debate, delegates had decided by a margin of only three votes to allow the meeting to debate the issue of whether the BMA “should adopt a neutral stance on assisted dying”.  Dr Andrew Mowat told delegates that BMA had debated the issue in seven of the last 10 ARMs.He pointed out that MPs voted by nearly three to one against changing the law to legalise assisted suicide last year, while the Scottish parliament had thrown out a similar bill months earlier.He said: “The public expect their doctors to lead on ethical issues. The thought of doctors killing patients creates public mistrust of us.”He said that evidence from other countries showed that when doctors’ organisations moved to a position of neutrality it was soon followed by legalisation of assisted suicide.Baroness Finlay, a crossbench peer and consultant in palliative medicine, and a leading opponent of legalisation, said: “With our hard-pressed healthcare system, doctors have enough to juggle without being saddled with assessing whose life is worth working hard to improve, and who should be given lethal drugs.”But Professor Clare Gerada, former chair of the Royal College of General Practitioners and a leading supporter of legalisation, said it was the BMA’s responsibility to debate the issue “year in, year out”.The disabled people’s campaign network Not Dead Yet UK (NDY UK), which opposes assisted suicide, welcomed the BMA vote, tweeting: “Thankyou to @BMA for continuing to oppose #assistedsuicide & listening to disabled people. Our lives are worth living,” and, “Disabled people will sleep safer tonight knowing @BMA doctors support us.”Baroness [Jane] Campbell, NDY UK’s founder, added on Twitter: “Great news! Not Dead UK thanks you from the bottom of our heart.”Dr Ian Wilson, chair of the BMA’s representative body, said: “Doctors appreciate the strongly-held views both across society and their profession on both sides of this complex and sensitive issue.“The issue of assisted dying has been regularly debated by the BMA at its annual policy-forming conference, with delegates voting this year to remain opposed to assisted dying.“By engaging with doctors and members of the public in an 18-month long project, we have compiled a comprehensive body of qualitative research to look at the wider context of the issue and enable members to have informed discussions at this year’s conference.“This work will still continue and we will also be holding a special open discussion this week during which doctors will be able to share their views on some of the more complex and practical issues doctors would face if assisted dying were permitted in the UK.”Picture: Not Dead Yet UK supporters protesting about the Marris bill outside parliamentlast_img read more

Uber Must Leave Italy in 10 Days After Nationwide Ban

first_img The only list that measures privately-held company performance across multiple dimensions—not just revenue. Add to Queue Mariella Moon Next Article Image credit: Pacific Press via Getty Images This story originally appeared on Engadget It can no longer advertise its services or operate in the country. Uber 2 min read Apply Now » Trouble seems to follow Uber wherever it goes. A court in Rome has just banned the ride-hailing service in Italy for contributing to what it says is “unfair competition” faced by the local taxi industry. Uber must now stop promoting its services and cease all operations in the country within 10 days, unless it’s willing to pay a $10,600 fine for each day it remains active after that grace period. While Uber’s $70 billion valuation makes that amount sound like chump change, it hasn’t exactly been profitable and actually bled billions in 2016.Uber’s situation in Italy is the same problem it typically deals with, albeit on a different day and in a different country. The company faced similar pushback from local taxi associations in France, the U.K. and other places around the globe, and it’ll no doubt happen again and again. In fact, this isn’t the first court battle it lost in the European country: a couple of years ago, a court in Milan banned the company’s UberPop application.Nevertheless, the company said in a statement that it’s “shocked” by the court’s decision and will file for an appeal. It added: “Thousands of professional, licensed drivers use the Uber app to make money and provide reliable transportation at the push of a button for Italians.” Until it changes the court’s mind, though, Uber’s Black, Lux, Suv, X , XL, Select and Van phone applications will have to say “ciao” to Italian commuters. –shares Uber Must Leave Italy in 10 Days After Nationwide Ban April 10, 2017 2019 Entrepreneur 360 Listlast_img read more

IBM Signals End of Telecommuting Craze

first_imgRemote Workforce Remote workers are strong proof that talking face to face is the best communication technology. Next Article IBM Signals End of Telecommuting Craze Author of Real Leaders Don’t Follow Free Webinar | July 31: Secrets to Running a Successful Family Business Steve Tobak Learn how to successfully navigate family business dynamics and build businesses that excel. VIP Contributor May 24, 2017 Register Now » 5 min read –shares Remember the time Marissa Mayer banned telecommuting at Yahoo and started a media firestorm? Some thought she’d flipped her lid. Others said she’d made a grave mistake that would kill morale. Well, she hadn’t and it didn’t. That was one of the few things she did right in her ill-fated attempt to turn around the hapless internet portal.While the former Googler didn’t intend to start a trend, she did. HP followed suit a few months later. Then came Best Buy, Bank of America, Aetna and others.Last week, IBM gave thousands of virtual workers an ultimatum: either show up in the office, or go work somewhere else. Considering that Big Blue pioneered the “anytime, anywhere workforce” decades ago, that sort of closes the books on what has turned out to be yet another overhyped management fad.Years ago, telecommuting was all the rage. Many predicted that, in the not-too-distant future, just about everyone would work remotely. Turns out, while working alone can boost productivity for some, the isolation can also have a chilling effect on collaboration and innovation. It’s sort of a mixed bag.Related: How Telecommuting Reduced Carbon Footprints at Dell, Aetna and XeroxWith decision-making becoming more real-time, data-centric and collaborative every day, it’s easy to see that a distributed workforce can slow the wheels of progress. It’s not at all surprising that nearly every company that’s put a stop to working remotely has been in a turnaround situation when team performance is critical.That’s why Apple spent billions to build Apple Park — its new spaceship-like headquarters with 175 acres of parkland and a 2.8 million square-foot main building that can house more than 12,000 employees. It’s all about collaboration and innovation. You’d think the tech giant would know something about that sort of thing.   The notion of overhyped management trends goes far beyond telecommuting. Every year or so the media goes bananas over a new fad. Enterprising opportunists then write books and start lucrative consultancies. There are always companies, big and small, that take the bait. Most end up regretting it, especially those who go for it hook, line and sinker.Related: 4 Reasons Telecommuting Can Be Bad for BusinessBack when I was a young up-and-comer, the big management trends were matrix management, core competency, management by objective, organizational development, six sigma and strategic planning. The hot books were The One Minute Manager, Guerilla Marketing, Crossing the Chasm and Good to Great.Granted, there was some benefit to most of those concepts. It was the hype that caused executives and business leaders to go overboard.One of the best examples of that was outsourcing pioneered by Peter Drucker, the father of modern management. The problem came when outsourcing turned into offshoring, and ended up exporting jobs and importing cheap labor. The result was the near extinction of America’s manufacturing sector.Today, we live in the golden age of overhyped fads: company culture, personal branding, content marketing, cause marketing, growth hacking, emotional intelligence, employee engagement, crowd funding, positive thinking, productivity, time management and, of course, everything Steve Jobs. There are countless books like The Lean Startup, Strengths Finder and Start With Why.As in the past, there is some value to most of those concepts, but again, overdoing it can do far more harm than good. The best recent example I can think of is the self-management craze. For a while, everyone was starting to question whether companies even needed bosses or titles anymore. It turns out that flatter organizational structures are indeed beneficial, but only to a point. As usual, some went overboard.Related: 5 Ways Telecommuting and Flex Time Help You Recruit the Best WorkersA book called Reinventing Organizations by Frederic Laloux popularized the controversial concept of teal or nonhierarchical, peer-to-peer organizational structures. Holacracy took it a step further. But Tony Hsieh’s move to take Zappos in that direction has been an unmitigated disaster. Twitter cofounder Ev Williams dropped Holacracy at Medium, which is currently trying to reinvent itself and its business model.In the early days of the company, Google cofounders Larry Page and Sergey Brin toyed with the notion of a completely flat organization without bosses. They finally came to their senses and realized that, while it might work for some companies of limited size, it simply wasn’t very practical or scalable for a growth-oriented company. Kudos to them.Look, I’ve been around a long time, long enough to see dozens if not hundreds of management fads come and go. The problem is when otherwise smart people stop thinking for themselves and start listening to the hype. They follow the crowd because all those people can’t be wrong. On the contrary, they can, and usually are.You know how there’s supposed to be so much wisdom in crowds? Nope: It’s just another fad. There’s no wisdom in crowds, just massive groupthink and herd mentality. You can’t beat the irony. As I say in my book, Real Leaders Don’t Follow: Leaders lead. Followers follow. You can’t do both. And that’s no hype. Opinions expressed by Entrepreneur contributors are their own. Image credit: Philippe Huguen | Getty Images Add to Queuelast_img read more

Business Leaders Slam Trumps Decision to Withdraw From Paris Climate Agreement

first_img Editorial Intern 4 min read Elon Musk, Mark Cuban and Mark Zuckerberg are among those who spoke out. This story originally appeared on Business Insider Business Leaders Slam Trump’s Decision to Withdraw From Paris Climate Agreement June 2, 2017 –shares Elon Musk is leaving Trump’s advisory council. Free Webinar | July 31: Secrets to Running a Successful Family Business Next Article Image credit: AP/Evan Vucci Learn how to successfully navigate family business dynamics and build businesses that excel. Government Mary Hanbury Add to Queue President Donald Trump announced Thursday that he will pull the U.S. out of the Paris climate agreement.The agreement, which was signed by 195 nations in December 2015, aims to slow down the rate at which the planet is warming.Before today’s decision was made, several executives of U.S. companies showed their disapproval of the U.S. pulling out of the agreement. On Wednesday, a letter signed by the executives of major companies, including Facebook, Google, Apple and Unilever, urged the president not to abandon the agreement.After Trump announced his decision, Tesla and SpaceX CEO Elon Musk said that he will be leaving Trump’s advisory council. Other executives have taken to social media to voice their concern.Jeff Immelt, chairman and CEO of General ElectricDisappointed with today’s decision on the Paris Agreement. Climate change is real. Industry must now lead and not depend on government.— Jeff Immelt (@JeffImmelt) June 1, 2017Elon Musk, CEO of Tesla and SpaceXAm departing presidential councils. Climate change is real. Leaving Paris is not good for America or the world.— Elon Musk (@elonmusk) June 1, 2017Satya Nadella, CEO of MicrosoftWe believe climate change is an urgent issue that demands global action. We remain committed to doing our part. https://t.co/Gfu7P2ESlL— Satya Nadella (@satyanadella) June 1, 2017Brad Smith, president of MicrosoftWe’re disappointed with the decision to exit the Paris Agreement. Microsoft remains committed to doing our part to achieve its goals.— Brad Smith (@BradSmi) June 1, 2017Aaron Levie, CEO of BoxWith so many things America needs to make substantial progress on, it’s incredibly disappointing to see us regress in significant areas.— Aaron Levie (@levie) June 1, 2017Mark Cuban, owner of NBA’s Dallas Mavericks1) If Dems are smart, they should call for immediate meetings w POTUS to determine how to get back in the Paris Agreement— Mark Cuban (@mcuban) June 1, 2017Lisa Jackson, vice president of environment, policy and social initiatives at Apple and former administrator of the U.S. Environmental Protection AgencyAddendum: minus ??. For the good of big coal.— Lisa P. Jackson (@lisapjackson) June 1, 2017Marc Benioff, CEO of SalesforceDeeply disappointed by President’s decision to withdraw from ParisAgreement. We will double our efforts to fight climate change. pic.twitter.com/cmCLf9CoVY— Marc Benioff (@Benioff) June 1, 2017Brent Saunders, CEO of Allergan$AGN is committed to doing our part to reduce climate change: decrease energy consumption, greenhouse gas, water use & waste by ~20% in 2020— Brent Saunders (@brentlsaunders) June 1, 2017Sundar Pichai, CEO of GoogleDisappointed with today’s decision. Google will keep working hard for a cleaner, more prosperous future for all.— Sundar Pichai (@sundarpichai) June 1, 2017Lloyd Blankfein, CEO of Goldman SachsToday’s decision is a setback for the environment and for the U.S.’s leadership position in the world. #ParisAgreement— Lloyd Blankfein (@lloydblankfein) June 1, 2017Mark Zuckerberg, CEO of FacebookBob Iger, chairman and CEO of The Walt Disney CompanyAs a matter of principle, I’ve resigned from the President’s Council over the #ParisAgreement withdrawal.— Robert Iger (@RobertIger) June 1, 2017Apple CEO, Tim CookDecision to withdraw from the #ParisAgreeement was wrong for our planet. Apple is committed to fight climate change and we will never waver.— Tim Cook (@tim_cook) June 2, 2017In an email to employees on Thursday, following Trump’s withdrawal announcement, Apple CEO Tim Cook said: “Climate change is real and we all share a responsibility to fight it. I want to reassure you that today’s developments will have no impact on Apple’s efforts to protect the environment.”Cook had phoned the White House earlier this week to urge President Donald Trump not to withdraw from the Paris climate deal. Register Now »last_img read more

Booker Harris Push Marijuana Legalization to Center Stage for 2020 Election

first_img Image credit: Pool | Getty Images Booker, Harris Push Marijuana Legalization to Center Stage for 2020 Election dispensaries.com Opinions expressed by Entrepreneur contributors are their own. Legal Marijuana Two senators who are leading candidates in the race for the Democratic presidential nomination have already accomplished something early in the campaign – they’ve made legalization of marijuana at the national level a primary issue.Sen. Cory Booker of New Jersey already has introduced legislation to remove marijuana from the federal list of illegal drugs and continues to take that position as a candidate. And Sen. Kamala Harris of California this month very publicly declared her support for legalizing pot on “The Breakfast Club” morning radio show in New York City.She couldn’t have been much more straightforward.“Let me just make this statement very clearly: I believe we need to legalize marijuana,” Harris said on the show. “Now, that being said – this is not a “but,’ this is an ‘and’ – and we need to research…the impact of weed on a developing brain.”She said leaders must also discuss a way to create standards for measuring impairment of drivers under the influence of marijuana.Related: This Week in Weed: High End Hemp!Much Ado About Nothing?That all seems clear, but of course there was an immediate political dustup over a side issue. In this case, it revolved around whether Harris listened to Tupac and Snoop Dogg when she tried marijuana in college (neither had released records before she graduated in 1986). Many media outlets reported she said this in the “Breakfast Show” interview.However, the video of the interview seems to show she was answering another host’s questions (there are multiple hosts) about music she listens to, not an interjected question about what she was listening to while using marijuana, according to the New York Times.The more important issue for cannabis entrepreneurs and consumers is that Harris, like Booker, put legalization of marijuana at the federal level on the front burner. When talking about using marijuana in college, Harris added, “and I inhaled.” That’s a reference to then-presidential candidate Bill Clinton’s statement in 1992 that he tried marijuana in college but “didn’t inhale.”The marijuana debate has come a long way in the intervening 27 years. What used to be the source of a “gotcha” question – “have you ever used marijuana?” – is now used by a candidate to talk about legalization.Related: 3 Compliance Considerations for Multi-State Cannabis BusinessesBooker Forces HandHarris, the former attorney general of California, had little choice but to take a position on the issue. Booker filed legislation in 2017 that called for removing marijuana as a Schedule I illegal drug. He’s remained a strong supporter of legalization.The Drug Enforcement Administration maintains the schedule of illegal drugs , which was started during the Nixon Administration in the early 1970s. It essentially launched the War on Drugs and led to creation of the DEA in 1973.Schedule I is for the most stringently restricted  illegal drugs. In the eyes of the federal government, marijuana is as dangerous and addictive as heroin and cocaine. That’s an official position that stands at odds with what state voters and legislatures have done. In 10 states, recreational marijuana is legal., while 33 states have legalized medical marijuana.Booker’s legislation not only would legalize pot, but also withhold federal funds from states that maintain marijuana laws that disproportionately impact minority communities.Arguments for legalization.What voters will hear over the next few months from politicians will likely revolve around the following arguments for legalization.The War on Drugs hurts minorities the most: FBI statistics show that blacks are 3.73 times more likely to get arrested for marijuana possession than whites, according to an analysis by the American Civil Liberties Union. The ACLU also reported that marijuana possession arrests account for more than half of all drug arrests. Harris mentioned this in her interview, noting that “young men of color” have been arrested at rates higher than other young men.The people have spoken: In vote after vote in state after state, people have approved both legal recreational and medical marijuana.Marijuana has health benefits: Few will come out and say that marijuana has health benefits, although a lot of research shows that is the case. But they will argue that more research needs to be done and that can’t happen with marijuana being illegal at the federal level.Treat it like alcohol: Even if they don’t argue any of the above, some politicians already are saying that marijuana should be made legal and regulated like alcohol, another substance that used to be illegal.How President Donald Trump will position himself on the issue is unclear. However, in June 2018 he said he’d “probably” support bipartisan legislation that lifted the federal ban on marijuana and leave it to the states to decide.To stay up to date on the latest marijuana-related news make sure to like dispensaries.com on Facebook Easy Search. Quality Finds. Your partner and digital portal for the cannabis community. Perhaps the greatest proof the American people have rejected the War on Drugs is that presidential candidates can favor legalization at no political cost. Add to Queue Next Article –shares Guest Writer Free Green Entrepreneur App Keep up with the latest trends and news in the cannabis industry with our free articles and videos, plus subscribe to the digital edition of Green Entrepreneur magazine. 5 min read February 19, 2019 Download Our Free Android Applast_img read more

SoundCommerce Closes 65 Million Seed Round Led by Defy Partners

first_imgAmazon Veterans Apply Data Science to Help Brands Transform Operations and Shopper ExperiencesData platform provider SoundCommerce has closed a $6.5 Million seed round led by Silicon Valley’s Defy Partners with participation from Voyager Capital of Seattle, Stage Venture Partners of Los Angeles, the Alliance of Angels and other notable investors. The funding coincides with SoundCommerce’s public launch as a data platform for commerce operations, and will accelerate the company’s hiring, platform development and customer engagement.“Delivering amazing consumer experiences is incredibly hard — it’s the reason brands that directly serve consumers are worth ten times their wholesaler counterparts,” said SoundCommerce CEO Eric Best. “You’ve acquired the shopper, and now it’s time to deliver on your customer promise. This is where SoundCommerce comes in.” Defy PartnersfundingMarketing TechnologyNewsSoundCommerceStage Venture Partners Previous ArticleVonage and Freshworks Enhance Customer Experience Via Multichannel CommunicationsNext ArticleStartup Studios Are the Next Big Thing in the VC Industry, Says Sky 21 SoundCommerce Closes $6.5 Million Seed Round Led by Defy Partners PRNewswireJuly 2, 2019, 2:33 pmJuly 2, 2019 center_img “For omnichannel brands like Lucky Brand navigating the market today, both shopper expectations and operational complexity are higher than ever,” said Michael Relich, COO at Lucky Brand, a SoundCommerce customer. “SoundCommerce helps us manage the business to the key metrics and service levels that drive our profitability and customer experience across channels.”Marketing Technology News: Creator by Zmags Brings Greater Agility to Ecommerce CreativitySoundCommerce, an Operations Data Platform (ODP) for consumer brands and retailers, transforms customer experience through better decisioning across merchandising, supply, fulfillment, delivery, and customer service. SoundCommerce tracks real-time operational events, profitability and customer lifetime value to answer questions fundamental to cross-channel and direct-to-consumer success, including:“Are we meeting our delivery promise?”“What’s driving and detracting from profitability?”“Are assortment, inventory and promotions aligned with demand?”“Which markets, channels, and customers should we prioritize?”“How should we treat this customer to balance profit with experience and LTV?”SoundCommerce connects data between systems and partners, monitors operations, enables business intelligence, and drives machine learning-enabled predictive decisioning. The platform is integrated with major commerce systems including Amazon.com, Shopify, Magento, Salesforce Commerce Cloud, StitchLabs, NetSuite, Dynamics 365, ReCharge and Salsify as well as common EDI formats and leading parcel post carriers.Marketing Technology News: Amperity and Snowflake Partner to Help Joint Customers Power Customer 360 Initiatives“SoundCommerce is poised to capitalize on the value of operations data, beginning with the massive and growing consumer goods and D2C industries,” said Neil Sequeira, Co-founder and Managing Director at Defy Partners. “While everyone else prioritizes marketing, Amazon.com has proven that modern, intelligent operations are paramount to retail success.” In conjunction with the financing, Sequeira joins SoundCommerce’s board of directors.SoundCommerce is founded by CEO Eric Best and CTO Jared Stiff, industry veterans with previous exits to Amazon, Liberty Interactive, and the public equity markets. SoundCommerce investors include Defy Partners, Voyager Capital, and the AoA. Stage Venture Partners and Kick-Start Partners led the company’s pre-seed financing.Marketing Technology News: Creator by Zmags Brings Greater Agility to Ecommerce Creativitylast_img read more

Scientists create comprehensive new method to predict breast cancer risk

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Jan 14 2019Scientists have created the most comprehensive method yet to predict a woman’s risk of breast cancer, according to a study by Cancer Research UK published in Genetics in Medicine.They have a developed a way of calculating the risk of developing the disease by combining information on family history and genetics with other factors such as weight, age at menopause, alcohol consumption and use of hormone replacement therapy.Although individually some of these things have a small impact on the likelihood of developing the disease, researchers found that by considering all of them at once, plus family history and genetics, they can identify groups of women who have different risks of developing breast cancer.Importantly, for the first time, researchers have taken into account more than 300 genetic indicators for breast cancer. This makes calculating the risk much more precise than ever before.From this, the researchers have created an online calculator for GPs to use in their surgeries. Some GPs, practice nurses and genetic counselors are testing this tool before it is considered for wider use. Doctors are prompted to answer a series of online questions about their patient including their medical and family history, whether they have any known genetic alterations linked to cancer, their weight and whether they drink alcohol.In the future, information like this could help to tailor breast cancer screening depending on an individual’s risk. For example, it could help determine what age they are first invited for breast screening or how regularly they are invited to receive it.The risk calculation could also help people to make decisions about preventative therapy – such as identifying women at high risk who may benefit from taking the drug tamoxifen – as well as encouraging women to think about the ways they could reduce the risk themselves, for example trying to keep a healthy weight.Related StoriesSugary drinks linked to cancer finds studyNew study to ease plight of patients with advanced cancerTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerProfessor Antonis Antoniou, lead author at the University of Cambridge, said: “This is the first time that anyone has combined so many elements into one breast cancer prediction tool. It could be a game changer for breast cancer because now we can identify large numbers of women with different levels of risk – not just women who are at high risk.”This should help doctors to tailor the care they provide depending on their patients’ level of risk. For example, some women may need additional appointments with their doctor to discuss screening or prevention options and others may just need advice on their lifestyle and diet. “We hope this means more people can be diagnosed early and survive their disease for longer, but more research and trials are needed before we will fully understand how this could be used.”Breast cancer is the most common cancer in the UK. Nearly 55,000 women are diagnosed with the disease each year. But a large proportion of breast cancer cases occur in people who are at an increased risk. Cancer Research UK has helped to double breast cancer survival over the last 40 years.Dr Richard Roope, Cancer Research UK’s GP expert, said: “Research like this is hugely exciting because in the future it will enable us to offer much more tailored care which will benefit patients and make best use of the services that we have available.”Although having an increased risk of breast cancer means a woman is more likely to develop the disease – it’s by no means a certainty. A woman at high risk may never get breast cancer just as a woman at low risk still could. But any woman with concerns should speak to her GP to discuss the options.”Source: https://www.cancerresearchuk.org/about-us/cancer-news/press-release/2019-01-15-researchers-develop-comprehensive-new-way-to-predict-breast-cancer-risklast_img read more

Exposure to antenatal corticosteroid therapy associated with reduced fetal growth

first_imgRelated StoriesPersonalizing Nutritional Medicine With the Power of NMRAntibiotic combination effective against drug-resistant PseudomonasNew strategy may strengthen gut-brain communicationGuidelines currently recommend one dose, repeated over 24 hours, of ACT to accelerate lung maturation in cases of threatened preterm birth. However, many exposed infants end up born at term and are therefore exposed unnecessarily to any potential harms of ACT. In the new study, researchers studied all live-born singleton births in Finland from 2006 through 2010. De-identified data were available on ACT exposure, birth weight, birth length, head circumference, Apgar scores, and medical care of infants.4,887 women (1.75%) were treated with ACT and, of those exposed, more than 44% (2173) of infants were born at term. Adjusted analyses showed significant differences in birth weight between exposed and unexposed infants, with an apparent reduction in birth weight of 61.54 grams for very preterm babies exposed to ACT (±SE 28.62, P<.03), 222.78 grams for preterm babies (±SE 19.64, P<.001), 159.25 grams for near term babies (±SE 19.14, P<.001), and 91.62 grams for term babies (±SE 11.86, P<.03). Associations were also seen for birth length and head circumference. There were no significant differences in Apgar scores, but ACT-exposed infants generally required greater medical care during the first seven days of life and beyond.“These findings provide strong evidence indicating that ACT is associated with reduced fetal growth in humans and provide an agenda for further studies,” the authors say. “Early care decisions need to identify high-risk patients and weigh benefits of ACT against potential harm of unnecessary exposure.” Credit: Fotorech, Pixabay Feb 28 2019Infants exposed to antenatal corticosteroid therapy (ACT) to accelerate lung maturation have a clinically significant reduction in birth size, according to a new of study of 278,508 births published this week in PLOS Medicine by Alina Rodriguez of the University of Lincoln and Imperial College London, UK, and colleagues.center_img Source:https://www.plos.orglast_img read more

Low levels of certain eye proteins could serve as predictor for Alzheimers

first_imgBy Sally Robertson, B.Sc.Mar 19 2019Researchers at Boston Medical Center have found that low eye-fluid levels of two proteins associated with Alzheimer’s could serve as a potential predictor of the disease. Shutterstock | Kuttelvaserova StuchelovaThe study showed that low levels of amyloid-β and tau proteins in the eye was significantly associated with poor cognitive scores.Alzheimer’s disease is characterized by abnormal levels of amyloid- β and tau, with amyloid proteins forming deposits in the brain many years before symptoms arise. Diagnosing and treating Alzheimer’s disease in the early stages, before symptoms present, significantly improves the chances of therapy being effective.Related StoriesEye research charity funds development of ‘organ-on-a-chip’ to fight glaucomaAmerican Academy of Ophthalmology shares tips for staying safe around fireworks’Eye-in-a-dish’ model helps scientists to uncover ‘surprising’ AMD gene variantThe study, which is the first to link ocular levels of the biomarkers with mental status, suggests that an eye test for the proteins could be a cost-effective, convenient way of predicting future Alzheimer’s risk.Studies have already shown that low levels of amyloid-β and tau in the cerebrospinal fluid (CSF) is associated with preclinical disease – where the pathological brain changes have started, but clinical symptoms have not yet developed. However, the lumbar puncture or “spinal tap” procedure that is used to obtain CSF is expensive and often inconvenient for patients to undergo.Now, ophthalmologist Lauren Wright and colleagues have tested eye fluid extracted from 80 patients who had previously undergone eye surgery. After determining the level of amyloid-β and tau in the samples, the team found that lower levels of the biomarkers were associated with lower scores on a baseline cognitive test the patients had taken.Furthermore, the cognitive test scores showed that some of the participants with low levels of the proteins already showed signs of mild-to-moderate dementia.”These findings could help us build an accessible, and minimally invasive test to determine Alzheimer’s disease risk, especially among patients with eye disease,” says Wright.The findings support previous research indicating that patients with eye disease may be at risk for Alzheimer’s disease. They also suggest that further studies of these patients may generate results that can be applied to the broader population.Senior author Manju Subramanian says the research represents a great step in establishing the important role the eye could in play diagnosing preclinical Alzheimer’s.“Further study is needed comparing protein biomarkers in the eye with more in-depth neurological testing,” he concludes. Source:https://www.eurekalert.org/pub_releases/2019-03/bmc-sft031819.phplast_img read more

Long delays in prescribing new antibiotics may threaten development of needed drugs

first_imgPrograms that push drugs to market could be combined with incentives that pull new antibiotics forward once they receive FDA approval, Rose says. Government stockpiling of drugs or a cash reward for meeting that milestone might help companies bridge the year-plus gap to a stable market.A recently proposed bipartisan bill in Congress, the DISARM Act, aims to institute some of these pull incentives. These sorts of programs could help ensure a steady stream of new antibiotics by providing more security after the drugs are approved.”I don’t know if this study has all the answers, but it starts the conversation,” says Rose. Source:University of Wisconsin–MadisonJournal reference:Rose, W.E. et al. (2019) Antimicrobial stewardship during a time of rapid antimicrobial development: Potential impact on industry for future investment. Diagnostic Microbiology & Infectious Disease. doi.org/10.1016/j.diagmicrobio.2019.06.009. Those incentives might not be enough. We have to think about things differently.”Warren Rose, professor in the School of Pharmacy, University of Wisconsin–Madison Reviewed by James Ives, M.Psych. (Editor)Jun 27 2019U.S. hospitals wait over a year on average to begin prescribing newly developed antibiotics, a delay that might threaten the supply or discourage future development of needed drugs.A survey of how 132 hospitals prescribed six new antibiotics from 2014 to 2018 found that the average time to prescribe any one of the new drugs was 398 days. Teaching and research hospitals and large hospitals tended to prescribe the drugs more quickly than smaller, non-academic hospitals.That gap period delays the payback of research and development costs in the crucial months following federal approval of a new drug. Those challenges could reduce the likelihood that companies develop new antibiotics, which are essential for treating pathogens that develop resistance to existing antimicrobials.Warren Rose, a professor in the School of Pharmacy at the University of Wisconsin–Madison who led the recent study, says this delay shows the need for market-boosting incentives to buoy new antibiotics during this sensitive period to ensure a robust supply of fresh antibiotics in the coming years and decades.He points to the pharmaceutical company Achaogen, which filed for bankruptcy earlier this year after its first drug, an antibiotic, failed to gain a market foothold.”If companies fail, then even if you call for drugs, they won’t make them,” says Rose. “As clinicians, we are hypocritical, because we call for drugs and then don’t use them.”Rose conducted the study with Lucas Schulz, the Infectious Diseases Coordinator in the Department of Pharmacy at UW Health, Seok Yeong Kim, a student at the School of Pharmacy, and Alyssa Hartsell from the health care consulting company Vizient. The team published its findings June 22 in the journal Diagnostic Microbiology and Infectious Disease.In response to the growing problem of antibiotic resistance, which affects millions of people in the U.S. each year, public and private organizations have provided funding and support to boost the development of new antibiotics. That support has worked -; 12 new antibiotics have received approval by the Food and Drug Administration since 2010, reversing decades of declining development.Those drugs include several Qualified Infectious Disease Products, an FDA label for antibiotics that are eligible for extended exclusive sale protections and rapid approval as incentives for development. Rose and his team tracked the prescription of six QIDPs over four years using a Vizient database.Related StoriesComputer-generated flu vaccine enters clinical trials in the USResearchers completely eliminate all traces of HIV from infected miceInnovative single-chip platform speeds up drug development processWhile the average time to use one of the new drugs was longer than a year, it varied widely from less than two weeks to more than four years. Hospitals with more complex patient needs, which tended to be larger hospitals and those associated with universities, prescribed the new drugs more quickly.Prescribing time also varied by region. The South prescribed all six drugs within two years on average, while the Northeast region took more than three and a half years to meet the same mark.It’s not entirely clear what drives this delay. These new drugs are much more expensive than legacy antibiotics -; up to $1,000 a day versus pennies for some older drugs -; which may account for some of the reluctance to begin prescribing them.More importantly, antibiotics work best when they are only used for the right patient at the right time, and there may be barriers to including the new drugs in these protocols. Many of the recently developed antibiotics target a wide range of bacteria, which means they do not meet antibiotic stewardship guidelines that recommend targeting pathogens with narrowly active antimicrobials.There are also few tests available for helping doctors determine whether a patient is a good candidate for these new drugs, which means they may only be prescribed after other antibiotics have failed to cure an infection. In all, these new antibiotics appear to function as a drug of last resort, delaying their use.Rose says current incentives for companies to produce new antibiotics end before the drugs are approved and go on sale, leaving companies in the lurch if uptake is slow.last_img read more

New biomaterial could encapsulate and protect implanted insulinproducing cells

first_imgUsing stem cellsThe project hopes to solve another barrier to cell-transplantation treatment, which is the need for large amounts of pancreatic cells from deceased donors. It has been using human stem cells that are driven to become insulin-producing cells.Researchers studied both encapsulated pancreatic islets and encapsulated human induced pluripotent stem cells to determine their behavior and functionality after implantation in preclinical models. These preclinical studies are also being finalized.The project’s multidisciplinary approach draws on synthetic biology, nanobiotechnology and molecular and cellular biology.The smart, bioengineered materials to be used in the ELASTISLET capsules are named elastin-like recombinamers and have not been tried before to treat diabetes. They are inspired by a natural protein, elastin, that is found in the body’s connective tissue. It can be manipulated to have multifaceted chemical, physical and biological properties.Related StoriesTAU’s new Translational Medical Research Center acquires MILabs’ VECTor PET/SPECT/CTObese patients with Type 1 diabetes could safely receive robotic pancreas transplantOlympus Europe and Cytosurge join hands to accelerate drug development, single cell researchThese advantages allow the capsules to mimic the natural tissue environment to ensure they do not provoke an immune response. The capsules are designed to allow the recipient’s blood vessels to grow on to them – but not into them, which would trigger an immune response.Other applications‘The smart biomaterials at the core of our therapeutic solutions have been emerging with extraordinary strength, not only in the field of cell therapy, but also in many different areas of biomedicine, such as regenerative medicine, tissue engineering and drug delivery,’ says Rodríguez-Cabello. ‘Our efforts thus contribute to provide further evidence of their versatility and extraordinary potential to impact on other diseases and conditions.’Type 1 diabetes leads to increased risk of developing an array of life-threatening problems, in the long term. Incorrect levels of glucose can result in damage to a variety of tissues and organs, in particular blood vessels, the heart and kidneys, the eyes and nerves.According to the project, the number of people with diabetes in Europe is expected to reach 38 million by 2030, increasing the financial burden on the health care system. Recent studies found that the overall cost of diabetes is estimated to exceed EUR 188 billion in the UK, Spain, Italy, France and Germany. A cost-effective solution such as the one the project is offering could help significantly reduce this.The project developed a maze game – Discover the Isle of Elastislet – as a part of a range of communication materials to spread the message about the disease and encourage learning while playing. The game is an educational project designed to reach teachers, pupils, parents and children with diabetes as well as the general public. Players answer simple questions about diabetes, while trying not to get lost, as they discover how the research is addressing cell transplantation treatments for the disease. Source:European Commission This project represents the preclinical phase of developing this bioengineered solution and we have been working on the bioproduction, chemical modification and characterization of the smart materials at the core of our encapsulation strategy. The project is in the process of finalizing these preclinical studies. Building on the success of this phase, we will soon be ready to start first-in-man clinical studies in type 1 diabetes patients.”José Carlos Rodríguez-Cabello, Project Coordinator, University of Valladolid, Spain Reviewed by Alina Shrourou, B.Sc. (Editor)Jul 4 2019Transplanting insulin-producing pancreatic cells into people with type 1 diabetes has emerged as a ground-breaking treatment for millions of patients over the past few decades. However, one of the barriers to its effectiveness is the body’s natural auto-immune response, which results in the death of the implanted cells.In response, the EU-funded ELASTISLET project developed a semi-permeable and biocompatible material to encapsulate and protect the implanted cells from immune attack while it is being integrated into the patient’s body.While impermeable to immune cells, antibodies and other unwanted visitors, the bio-coating allows oxygen, nutrients and glucose into the protective capsule, and insulin to enter the bloodstream.last_img read more