New South Wales Combined Catholic Colleges have survived a late comeback from the Queensland Secondary Schools Touch side to win the title at the 2009 X-Blades National Youth Championships.CCC got out to a three touchdown lead before QSST hit back to level the game with minutes remaining.QSST had the opportunity to again level the scores late in the game when CCC’s Edan Price got sent to the sin bin with less than two minutes remaining, but were unable to capitalise, with the NSW boys taking the game by one touchdown. QSST got off to a great start when Ryley Jacks dived across the line in the opening set of six to give his side the early lead. It wasn’t long before CCC hit back, with Alex Franklin on the receiving end off a great flick pass from Daniel Chiddy, to level the scores at 1-all.Edrick Lee put QSST back in front five minutes later when he crossed over in the corner to give his side a 2-1 lead. But it was Scott Daley’s touchdown in the ninth minute, set up by Sam Brisby, which leveled the scores up again. CCC then hit the lead for the first time in the game when Simon Lang’s dive for the try line gave his side a 3-2 lead.CCC extended their lead four minutes later when a cut out pass from Brisby set up Alex Franklin for his second to give his side a three touchdown lead with minutes remaining in the first half.But QSST weren’t finished for the half, with Jacks crossing for second touchdown just before half-time to go to the break down by two, 5-3. CCC was back on the attack just after half-time, and extended their lead back to three touchdowns when Ben Dosseter scored in the first set of six. QSST’s Kade Bonner was the next to score, and brought his side back within two touchdowns with 13 minutes remaining, and when Lee crossed for his second, the Queensland boys were back in the game.Adam Pryde’s touchdown leveled the scores for QSST, but it was short lived, with Nicholas Good scoring off the next set of six off the back of some great work by Matt Moylan to steal the lead back, 7-6.Price was sent to the bin with two minutes remaining to give the QSST boys a chance to hit back, but it was too little too late, with CCC running away with the title.CCC was rewarded for their consistent carnival, with Moylan being named Player of the Match, and Good being named Player of the Series. NSWCCC Captain Dan Mahoney paid tribute to his team mates in the presentations after the game. “We’re all mates and that’s what it’s all about, that’s why we play touch,” Mahoney said.
jamal danley facebook postIn 2014, Oklahoma posted an 8-5 record, finished fourth in the Big 12, and got blasted by Clemson in the Russell Athletic Bowl, 40-6. In the offseason, the Sooners made a number of coaching changes – especially on the offensive side of the ball – in an attempt to reestablish dominance in the conference. A year later, they’re 11-1 and a lock to make the College Football Playoff.Tuesday, junior offensive lineman Jamal Danley, who was a four-star JUCO transfer this year, posted a Facebook message that was written to him while he was making his decision on where to play in 2015. The post, which looks to have been sent by a fan, focuses on Oklahoma’s demise and calls Danley “SEC material.” Danley clearly finds it amusing, seeing where OU is right now.1 year later! pic.twitter.com/Z9HiJrX8NG— Jamal Danley™ (@JDanley54) November 30, 2015Oklahoma has off this week as it prepares for to play for a national championship. Apparently, not everyone saw that coming a year ago.
Anyone with information to assist the police are asked to call Tumbler Ridge RCMP at (250) 242-5252. TUMBLER RIDGE, B.C. – The search for a Dawson Creek man who went missing near Kinuseo Falls nearly three weeks ago will be resuming this weekend.Cpl. Madonna Saunderson with North District RCMP said in a release that Search and Rescue units, as well as police, will be resuming the official search on Saturday for the 29-year-old man. The man is believed to have fallen into the Murray River near the bottom of Kinuseo Falls while on a camping trip sometime during the overnight hours on June 9th or 10th.Cpl. Saunderson said on June 12th that after an extensive search conducted on the water with jet boats and in the air with a helicopter and a fixed-wing aircraft for two days, that officials suspended the search because the fast-moving water in the Murray River was hampering search efforts.
If you are interested in knowing more about the changes happening in the Senate, Senator Woo will shed light on how Senate reform has led the Senate in a direction that is less partisan; more diverse in background, gender, and qualifications. FORT ST. JOHN, B.C. – The Comunity Development Institute is hosting their Leaders Lab Series with guest speaker Senator Yuen Pau Woo.On Wednesday, July, 17th, 2019 at the Northern Lights College, Room 202, at 7 pm join in this free talk by Senator Yuen Pau Woo an independent Senator representing British Columbia.
France’s Centre National du Cinéma et de l’Image Animée (CNC) has unveiled changes to the way it supports film production in the country, with producers able to access funding automatically if they accumulate a number of points granted for meeting certain criteria.CNC president Frédérique Bredin said that the system required reform in the light of changes to the way the sector worked, driven by digitization and the internationalization of production.The CNC said that the new points system would take into account factors such as the rise in importance of digital visual effects, but would also give additional credit for the extent to which a film is produced in France. Bredin said that the latter move would, alongside the implementation of new tax credits, boost production activity in France. He said the system would also place greater value on the work of writers, graphics designers and other professionals involved in the creative process. The system will also be geared towards the support of French-language production.The move follows a report compiled by Alain Sussfeld last year and a consultation with industry stakeholders including groups representing writers, producers, distributors and others.Writers copyright collection society SACD welcomed the changes – in particular the attribution of an additional point to authors in the 100-point scale used to assess projects, and additional recognition for scriptwriters.
Twenty-first Century Fox has increased its offer for Sky to £24.5 billion (€27.7 billion), outbidding rival Comcast which made a £22.1 billion approach for the pay TV operator earlier this year.Fox’s increased offer of £14 for each Sky share marks a 12% premium on Comcast’s £12.50 per-share offer and is roughly 30.2% higher than the initial offer price that it tabled in late 2016.Fox’s initial £10.75 per-share offer for the 61% it doesn’t already own of Sky had valued the operator at some £18.5 billion – a premium of approximately 40% on Sky’s closing share price on December 6, 2016, the last business day before Sky received the Fox offer.The new offer by Fox marks a premium of approximately 82.1% on that same December 6, 2016 closing price of £7.69 per Sky share. However, it is slightly below the price that Sky’s shares have been trading at this week.In a statement, 21st Century Fox said: “We strongly believe that a combined 21CF and Sky will be a powerful driver for the continued growth and vibrancy of the UK and broader global creative industries.”News of the improved offer comes after the UK government last month accepted deal terms between 21st Century Fox and Sky, following an improved commitment from Disney to operate Sky News for a period of 15 years.Then-UK culture secretary Matt Hancock said that new deal terms had been offered that meet the criteria he laid out in parliament earlier the same month – namely that that Sky News remains financially viable over the long term; is able to operate as a major UK-based news provider; and is able to make editorial decisions that are free from any outside influence.Final sign-off from the UK government is expected this week, following a 15-day consultation on the matter, which ended on July 4.Independent telecoms and media analyst, Paolo Pescatore, said: “There’s no way that Disney, nor 21st Century Fox want to let Sky go to Comcast. Therefore, expect another round of counter bids. The price is heading in one direction. It’s a great time to be a Sky shareholder.”
In This Issue… * BOC hints of rate hikes… * Overnight currency rally fades… * PM Gillard tests Chuck’s patience… * RIP Dick Clark… And, Now, Today’s Pfennig For Your Thoughts! More Gyrations… Good day… And a Tub Thumpin’ Thursday to you! Well, my beloved Cardinals did a Tub Thumpin’ on the Reds last night, so they got started on Thursday early! Have you ever heard the Rev. Al Green sing How Can You Mend A Broken Heart? Well, that’s what’s playing as I begin today’s letter, and I have to say that hearing the Rev. sing, really starts my day right! Well… the gyrations and volatility continue in the markets, one day up the next day down. One day a piece of data matters, the next day it doesn’t… But we carry on in spite of these daily movements back and forth… For instance, the euro is rallying this morning, which gives all the other currencies a chance to spread their wings… Spain was able to auction their target maximum amount of euro bonds this morning, and while the yield rose from the last time 10-year bonds were auctioned, the fact that the whole allotment went off without a hitch, is giving the euro some breathing room this morning. For those of you keeping score at home, in January, Spain issued 10-year Gov’t bonds at a yield of 5.403%… This time, they had to sweeten the pie a bit for buyers to take a bite of the debt ridden nation’s offerings… The current auction saw 10-year yields rise to 5.743%.. France also auctioned some debt issues this morning, and they too say yields rise… As I keep telling you, and anyone in the U.S. Gov’t that will listen… This is what will happen to us someday… the markets will demand a higher yield to take on more U.S. Debt… This U.S. Debt really gets me riled up… but the thing I keep coming back to, is that most Americans have no idea the depth of the Debt here in the U.S. I saw a story headline come across the Bloomberg this morning, that said, “World’s Richest Worth $1 Trillion.” The story went on to say that the 40 richest individuals on Earth are worth $1 Trillion… OK, think about that for a minute… If the 40 richest individuals gave everything they had to the U.S. to pay down the Debt, it wouldn’t make a difference, really… In fact, it would take the current Congress about 9 months and they would go right through those riches… Does that help illustrate how bad our debt has gotten? Or.. how about this… The total National Assets are $83.3 Trillion… The total U.S. Unfunded Liabilities are $118.5 Trillion… If each taxpayer were to “ante up” and give the Gov’t money to pay off our Unfunded Liabilities, each taxpayer would have to put up $1,045,026.00… A million dollars! I don’t make these numbers up folks… each Friday, I give you a link to the U.S. Debt Clock… here it is for you to look at… http://www.usdebtclock.org/index.html Ok… sorry I went off on that tangent with Debt… But, I’ve been banging this Debt drum for over a decade now, and believe me now and hear me later, the Debt was nowhere near where it is today… Back to the currencies… Well the Bank of Canada (BOC) left rates unchanged the other day, and tried to throw the markets a bone, by saying that stimulus could be removed sooner than later… But since then, the BOC has made an upward revision to their forecast for 2012 GDP from 2% to 2.4%. They also said that they believed the Canadian economy would hit its capacity limit in the first half of 2013, with economic growth then moderating the remainder of 2013… OK, that’s all well and good, but what about now? If the BOC believes that GDP growth is stronger than they previously did, then why aren’t interest rates going higher right here, right now? Well… I’ve explained this before, but just to review, the BOC can’t wander too far away from the interest rates in the U.S., which we’ve been told by more than a handful of Fed Heads that they will remain near zero through 2014… And I totally dislike the saying, “but this time it will be different”… So… I’ll just say that the BOC is going to have to wander from the U.S. near zero rates, because, inflation is going to be a real problem in Canada if they don’t! So… here I am, sitting here in St. Louis, Mo. And I see rate hikes in Canada… Where are all the “large research departments” with their calls for Canadian rate hikes? OK, Chuck, quit rubbing it in, these rate hikes haven’t happened yet, so you had better be careful calling out the “large research departments”… Ok… let’s mark this down, right here, right now, there is no other place I’d rather be, no wait! Come on Chuck, people don’t read this to see Jesus Jones songs! OK, I apologize, that was my evil twin that took over the Pfennig for a minute… But I’m back now, and I want to say that I think we’ll see one rate hike of 25 Basis Points (1/4%) before year-end, bringing the internal rates in Canada to 1.25%… But, in the first half of 2013, we could see the BOC really ratchet up the rate hikes… Can you say 2% by the end of 2013? And where will U.S. rates be? Still near zero… But just keep the legal beagles happy… This is just what I see, it’s my opinion, and I could be wrong… The euro has sold off by 1/4-cent since I came in, so the gyrations continue… Over in Japan, I’m still not used to saying this, but Japan posted another Trade Deficit, although it was weaker than forecast (Yen 82.6 Billion VS forecast Yen 223 Billion)… But still, no matter the size, it’s still strange to report a Trade Deficit for Japan… the yen traded off, or sold off either one, pick the one you like, but yen is weaker this morning on the Trade Deficit news… Apparently, the markets are like me, and seeing the Japanese Trade Balance in red still shocks them… In Australia… things are getting pretty hairy regarding the May Reserve Bank of Australia (RBA) meeting… I told you earlier this week that the RBA tied their monetary policy to the outcome of the 1st QTR CPI (inflation), which is set to print on April 24th… But last night, Prime Minister (PM) Gillard argued that the Gov’t’s plans to return to a budget surplus this year would give the RBA scope to cut rates… OK.. two things pop into my head when I read that statement by Gillard… 1. That she must know something about the CPI report next week, so she’s trying to persuade the RBA to look past the CPI report and to the plans for a budget surplus… or.. 2. She’s trying to apply pressure to the RBA to cut rates… I have quite a few Aussie readers of the Pfennig, and they send me notes all the time, telling me of their dislike for the PM… Hmmm… I now see why! The RBA used to be completely independent, but if they go ahead and cut rates next month, they are going to appear to be under the thumb of the PM… The Aussie dollar (A$) is weaker this morning on those comments by Gillard… When will Gov’t leaders learn to keep their hands out of the cookie jar? When will they ever learn? When, will, they, ever, learn? And this just came across the screens… The Brazilian Central Bank (BCB) cut rates this morning 75 Basis points (3/4%)… That’s a shocker to me, in that while I know that the BCB and the Brazilian Gov’t believe they are in a currency war, and need to get the real weaker, I really didn’t see them going to this length… But they have, and like I said the other day, I’m not sure the currency market guys are willing to fight them any longer… They are going to do a Dieter… and that won’t be good for the real… I haven’t mentioned Gold (& Silver) for a couple of days… I can tell you this… that most observers of the precious metals that have done this for some time, and not your Johnny-come-lately crowd, believe that Gold is simply forming a base here before it moves higher once again… but, the chart guys don’t see it that way… So… you choose your sword here… Me? After all these years of reading and researching these two metals, I can’t change horses in the middle of the stream here… My colors are still pinned to the mast of higher values for Gold & Silver… But remember that’s just my opinion, and maybe the chart guys are right… And the price of Oil remains above $100… I see where the President is going to get his hands in the cookie jar… I have to say that all the things I’ve told you in the past about why Oil prices are high are very important to keep in mind, when you hear politicians spouting off about those “evil Oil companies”… The cost of getting Oil out of the ground continues to rise… Think about that.. Yes, we’ve found all sorts of oil deposits, but it’s not like we can go out and stick an oil rig in the ground and start pumping oil! Any way… that’s just one of the things that keep the price of Oil high… But it’s not manipulated markets, folks… There’s just too many trades going in and out of Oil and no concentrated positions… This is not Gold & Silver, folks… Yes the price if high, and I don’t like it… But the price of just about everything these days is higher… Where’s all the complaining from the Gov’t that a beer at a ballgame costs $9? Don’t even get me started on this stuff, we could be here all day, I think you get my point here… And that brings me inflation here in the U.S. I’m not buying the story in the Bloomberg today about how the Bureau of Labor Statistics has all these people around the country going out and checking the prices of items for the calculation of inflation… Yes, maybe they do that, but that’s just one piece of the puzzle folks… I’ve told you for years about the “substitutions” that are made in the CPI calculation.. I’ve told you about the adjustments that are made to the weightings of items, and I’ve told you about this whole housing thing… it’s in the calc, then it’s not… right now they use “owner’s equivalent rent” which replaces the cost of owning a home with what it cost to rent it… How dumb is that? So… as I get ready to head to the Big Finish today… I want you to keep in mind a couple of things… that you don’t want to get mixed up in the gyrations… and everything isn’t as it appears to be… you have to look closer… Then There Was This… Ok… yesterday I gave you a couple of items that scare the bejeebers out of me… but forgot one that I was going to talk about… it goes like this: The WSJ reported that the U.N. had agreed to send “observers” to Syria… How about you? Does the word Observer when it comes to observing a war bother you? It does me… Vietnam comes to mind… and several places since then that the U.S. was just an “observer”… And yes, I know it says the “U.N.” not the U.S. but do we really think there’s a difference? To recap… The euro is leading a currency rally on the good news from Spanish and French bond auctions this morning… Both sold their maximum target of bonds, but both also saw yields rise. The Bank of Canada is greasing the tracks for a rate hike by raising their forecasts for GDP growth in 2012 and 13… Aussie PM, Gillard, is doing her best to get on Chuck’s persona non gratis list… And Chuck takes us on a ride to visit the Debt Clock… Currencies today 4/19/12… American Style: A$ $1.0365, kiwi .8185, C$ $1.0110, euro 1.3115, sterling 1.6030, Swiss $1.0915, … European Style: rand 7.8220, krone 5.7440, SEK 6.7320, forint 226.25, zloty 3.1860, Koruna 18.9150, RUB 29.49, yen 81.70, sing 1.2510, HKD 7.76, INR 51.98, China 6.3037, pesos 13.17, BRL 1.8780, Dollar Index 79.62, Oil $103.02, 10-year 1.99%, Silver $31.55, and Gold… $1,639.60 That’s it for today… RIP Dick Clark… I remember watching American Bandstand with my older sisters when I was young, and we would try to do the dances they did on TV… And before going out on New Year’s Eve was viable, I watched Dick Clark’s rockin’ New Year… I made a mistake yesterday and said our Blues played last night, but they play tonight, sorry to all that made a point of telling me I was wrong… So… Go Blues tonight! A day game at Busch Stadium today… hint, hint… Alex came home dead tired last night, after a good water polo game on the other end of town… Some of these schools are so far away, but still in the same conference… strange… And little Braden Charles (B, as we call him) was at the house yesterday… he’s a scooter… he doesn’t crawl, he goes across the floor, Army style… funny stuff! OK… time to go, thanks for reading the Pfennig, I hope you have a Tub Thumpin’ Thursday! Chuck Butler President EverBank World Markets 1-800-926-4922 1-314-647-3837 www.everbank.com
STAR EVENT: Hull City v Bristol CityKC Stadium TIME: 7.45pm TV: SKY37 points separate them in the Championship and it’s long odds-on at the end of the season there will be two leagues between Hull City and Bristol City.Hull need just four points to seal promotion to the Premier League whilst Bristol City are already condemned to League One after their defeat to Birmingham on Tuesday.If Bristol City were to achieve the impossible and win tonight – that would ensure leaders Cardiff City were crowned champions of the Championship without kicking a ball.But we don’t say impossible lightly, as it really is hard to envisage anything other than a Hull win and it could well be a convincing one.The win odds are tight, obviously, but there are two things that we at Star Sports think will happen.Firstly, there will be over 2.5 goals. There’s no reason for this game to be cagey. Bristol City are already down so will play free flowing football rather than cautiously whilst Hull are as good as up and will want to show off in front of their home crowd tonight.The reverse fixture resulted in a 2-1 win for Hull in October and the same fixture last season a more convincing 3-0 win for Hull.We can’t see anything beyond a Hull win, and plenty of goals.STAR FORECAST(stake between 0.5 and 10 points)5 points HULL-HULL HT/FT5 points over 2.5 goals(-3 points Wednesday)Agree OR disagree? Call Star Sports on 08000 521 321 to place your bet.
Remote Workforce Remote workers are strong proof that talking face to face is the best communication technology. Next Article IBM Signals End of Telecommuting Craze Author of Real Leaders Don’t Follow Free Webinar | July 31: Secrets to Running a Successful Family Business Steve Tobak Learn how to successfully navigate family business dynamics and build businesses that excel. VIP Contributor May 24, 2017 Register Now » 5 min read –shares Remember the time Marissa Mayer banned telecommuting at Yahoo and started a media firestorm? Some thought she’d flipped her lid. Others said she’d made a grave mistake that would kill morale. Well, she hadn’t and it didn’t. That was one of the few things she did right in her ill-fated attempt to turn around the hapless internet portal.While the former Googler didn’t intend to start a trend, she did. HP followed suit a few months later. Then came Best Buy, Bank of America, Aetna and others.Last week, IBM gave thousands of virtual workers an ultimatum: either show up in the office, or go work somewhere else. Considering that Big Blue pioneered the “anytime, anywhere workforce” decades ago, that sort of closes the books on what has turned out to be yet another overhyped management fad.Years ago, telecommuting was all the rage. Many predicted that, in the not-too-distant future, just about everyone would work remotely. Turns out, while working alone can boost productivity for some, the isolation can also have a chilling effect on collaboration and innovation. It’s sort of a mixed bag.Related: How Telecommuting Reduced Carbon Footprints at Dell, Aetna and XeroxWith decision-making becoming more real-time, data-centric and collaborative every day, it’s easy to see that a distributed workforce can slow the wheels of progress. It’s not at all surprising that nearly every company that’s put a stop to working remotely has been in a turnaround situation when team performance is critical.That’s why Apple spent billions to build Apple Park — its new spaceship-like headquarters with 175 acres of parkland and a 2.8 million square-foot main building that can house more than 12,000 employees. It’s all about collaboration and innovation. You’d think the tech giant would know something about that sort of thing. The notion of overhyped management trends goes far beyond telecommuting. Every year or so the media goes bananas over a new fad. Enterprising opportunists then write books and start lucrative consultancies. There are always companies, big and small, that take the bait. Most end up regretting it, especially those who go for it hook, line and sinker.Related: 4 Reasons Telecommuting Can Be Bad for BusinessBack when I was a young up-and-comer, the big management trends were matrix management, core competency, management by objective, organizational development, six sigma and strategic planning. The hot books were The One Minute Manager, Guerilla Marketing, Crossing the Chasm and Good to Great.Granted, there was some benefit to most of those concepts. It was the hype that caused executives and business leaders to go overboard.One of the best examples of that was outsourcing pioneered by Peter Drucker, the father of modern management. The problem came when outsourcing turned into offshoring, and ended up exporting jobs and importing cheap labor. The result was the near extinction of America’s manufacturing sector.Today, we live in the golden age of overhyped fads: company culture, personal branding, content marketing, cause marketing, growth hacking, emotional intelligence, employee engagement, crowd funding, positive thinking, productivity, time management and, of course, everything Steve Jobs. There are countless books like The Lean Startup, Strengths Finder and Start With Why.As in the past, there is some value to most of those concepts, but again, overdoing it can do far more harm than good. The best recent example I can think of is the self-management craze. For a while, everyone was starting to question whether companies even needed bosses or titles anymore. It turns out that flatter organizational structures are indeed beneficial, but only to a point. As usual, some went overboard.Related: 5 Ways Telecommuting and Flex Time Help You Recruit the Best WorkersA book called Reinventing Organizations by Frederic Laloux popularized the controversial concept of teal or nonhierarchical, peer-to-peer organizational structures. Holacracy took it a step further. But Tony Hsieh’s move to take Zappos in that direction has been an unmitigated disaster. Twitter cofounder Ev Williams dropped Holacracy at Medium, which is currently trying to reinvent itself and its business model.In the early days of the company, Google cofounders Larry Page and Sergey Brin toyed with the notion of a completely flat organization without bosses. They finally came to their senses and realized that, while it might work for some companies of limited size, it simply wasn’t very practical or scalable for a growth-oriented company. Kudos to them.Look, I’ve been around a long time, long enough to see dozens if not hundreds of management fads come and go. The problem is when otherwise smart people stop thinking for themselves and start listening to the hype. They follow the crowd because all those people can’t be wrong. On the contrary, they can, and usually are.You know how there’s supposed to be so much wisdom in crowds? Nope: It’s just another fad. There’s no wisdom in crowds, just massive groupthink and herd mentality. You can’t beat the irony. As I say in my book, Real Leaders Don’t Follow: Leaders lead. Followers follow. You can’t do both. And that’s no hype. Opinions expressed by Entrepreneur contributors are their own. Image credit: Philippe Huguen | Getty Images Add to Queue
Source:https://www.uq.edu.au/news/article/2019/02/potential-link-between-vitamin-d-deficiency-and-loss-of-brain-plasticity Reviewed by Alina Shrourou, B.Sc. (Editor)Feb 20 2019University of Queensland research may explain why vitamin D is vital for brain health, and how deficiency leads to disorders including depression and schizophrenia.Associate Professor Thomas Burne at UQ’s Queensland Brain Institute led the studies, which provide the groundwork for research into better prevention and treatments.”Over a billion people worldwide are affected by vitamin D deficiency, and there is a well-established link between vitamin D deficiency and impaired cognition,” Dr Burne said.”Unfortunately, exactly how vitamin D influences brain structure and function is not well understood, so it has remained unclear why deficiency causes problems.”Dr Burne’s team found that vitamin D levels affect a type of ‘scaffolding’ in the brain, called perineuronal nets.Related StoriesPosterior parietal cortex plays crucial role in making decisions, research showsNeural pathways explain the relationship between imagination and willingness to helpNew therapy shows promise in preventing brain damage after traumatic brain injury”These nets form a strong, supportive mesh around certain neurons, and in doing so they stabilise the contacts these cells make with other neurons,” he said.Researchers removed vitamin D from the diet of a group of healthy adult mice, and after 20 weeks found a significant decline in their ability to remember and learn compared to a control group.Dr Burne said the vitamin D deficient group had a pronounced reduction in perineuronal nets in the hippocampus, the brain region crucial to memory formation.”There was also a stark reduction in both the number and strength of connections between neurons in that region.”Dr Burne’s team propose that vitamin D plays an important role in keeping perineuronal nets stable, and that when vitamin D levels drop, this ‘scaffolding’ is more easily degraded by enzymes.”As neurons in the hippocampus lose their supportive perineuronal nets, they have trouble maintaining connections, and this ultimately leads to a loss of cognitive function.”Associate Professor Burne said the hippocampus may be most strongly affected by vitamin D deficiency because it is much more active than other brain regions.”It’s like the canary in the coalmine–it might fail first because its high energy requirement makes it more sensitive to the depletion of essential nutrients like vitamin D.”Intriguingly, the right side of the hippocampus was more affected by vitamin D deficiency than the left side.”Associate Professor Burne said loss of function in this area could be an important contributor to the hallmarks of schizophrenia, including severe memory deficits and a distorted perception of reality.”The next step is to test this new hypothesis on the link between vitamin D deficiency, perineuronal nets and cognition,” he said.”We are also particularly excited to have discovered these nets can change in adult mice.”I’m hoping that because they’re dynamic there is a chance that we can rebuild them, and that could set the stage for new treatments.”
Programs that push drugs to market could be combined with incentives that pull new antibiotics forward once they receive FDA approval, Rose says. Government stockpiling of drugs or a cash reward for meeting that milestone might help companies bridge the year-plus gap to a stable market.A recently proposed bipartisan bill in Congress, the DISARM Act, aims to institute some of these pull incentives. These sorts of programs could help ensure a steady stream of new antibiotics by providing more security after the drugs are approved.”I don’t know if this study has all the answers, but it starts the conversation,” says Rose. Source:University of Wisconsin–MadisonJournal reference:Rose, W.E. et al. (2019) Antimicrobial stewardship during a time of rapid antimicrobial development: Potential impact on industry for future investment. Diagnostic Microbiology & Infectious Disease. doi.org/10.1016/j.diagmicrobio.2019.06.009. Those incentives might not be enough. We have to think about things differently.”Warren Rose, professor in the School of Pharmacy, University of Wisconsin–Madison Reviewed by James Ives, M.Psych. (Editor)Jun 27 2019U.S. hospitals wait over a year on average to begin prescribing newly developed antibiotics, a delay that might threaten the supply or discourage future development of needed drugs.A survey of how 132 hospitals prescribed six new antibiotics from 2014 to 2018 found that the average time to prescribe any one of the new drugs was 398 days. Teaching and research hospitals and large hospitals tended to prescribe the drugs more quickly than smaller, non-academic hospitals.That gap period delays the payback of research and development costs in the crucial months following federal approval of a new drug. Those challenges could reduce the likelihood that companies develop new antibiotics, which are essential for treating pathogens that develop resistance to existing antimicrobials.Warren Rose, a professor in the School of Pharmacy at the University of Wisconsin–Madison who led the recent study, says this delay shows the need for market-boosting incentives to buoy new antibiotics during this sensitive period to ensure a robust supply of fresh antibiotics in the coming years and decades.He points to the pharmaceutical company Achaogen, which filed for bankruptcy earlier this year after its first drug, an antibiotic, failed to gain a market foothold.”If companies fail, then even if you call for drugs, they won’t make them,” says Rose. “As clinicians, we are hypocritical, because we call for drugs and then don’t use them.”Rose conducted the study with Lucas Schulz, the Infectious Diseases Coordinator in the Department of Pharmacy at UW Health, Seok Yeong Kim, a student at the School of Pharmacy, and Alyssa Hartsell from the health care consulting company Vizient. The team published its findings June 22 in the journal Diagnostic Microbiology and Infectious Disease.In response to the growing problem of antibiotic resistance, which affects millions of people in the U.S. each year, public and private organizations have provided funding and support to boost the development of new antibiotics. That support has worked -; 12 new antibiotics have received approval by the Food and Drug Administration since 2010, reversing decades of declining development.Those drugs include several Qualified Infectious Disease Products, an FDA label for antibiotics that are eligible for extended exclusive sale protections and rapid approval as incentives for development. Rose and his team tracked the prescription of six QIDPs over four years using a Vizient database.Related StoriesComputer-generated flu vaccine enters clinical trials in the USResearchers completely eliminate all traces of HIV from infected miceInnovative single-chip platform speeds up drug development processWhile the average time to use one of the new drugs was longer than a year, it varied widely from less than two weeks to more than four years. Hospitals with more complex patient needs, which tended to be larger hospitals and those associated with universities, prescribed the new drugs more quickly.Prescribing time also varied by region. The South prescribed all six drugs within two years on average, while the Northeast region took more than three and a half years to meet the same mark.It’s not entirely clear what drives this delay. These new drugs are much more expensive than legacy antibiotics -; up to $1,000 a day versus pennies for some older drugs -; which may account for some of the reluctance to begin prescribing them.More importantly, antibiotics work best when they are only used for the right patient at the right time, and there may be barriers to including the new drugs in these protocols. Many of the recently developed antibiotics target a wide range of bacteria, which means they do not meet antibiotic stewardship guidelines that recommend targeting pathogens with narrowly active antimicrobials.There are also few tests available for helping doctors determine whether a patient is a good candidate for these new drugs, which means they may only be prescribed after other antibiotics have failed to cure an infection. In all, these new antibiotics appear to function as a drug of last resort, delaying their use.Rose says current incentives for companies to produce new antibiotics end before the drugs are approved and go on sale, leaving companies in the lurch if uptake is slow.
Netflix to borrow another $2B to pay its programming bills Someone is standing up to television’s Goliath, with a prominent competitor saying Monday that Netflix is deceiving the public about what is a hit and what isn’t. Citation: FX chief says Netflix exaggerates viewership numbers (2019, February 5) retrieved 17 July 2019 from https://phys.org/news/2019-02-fx-chief-netflix-exaggerates-viewership.html Netflix puts its money where its mouth is: In 2018, the streaming platform said it was spending $8 billion on programming, the vast majority of it original. Since 2014, programming from Netflix and other, less robust streamers has increased nearly 400 percent, compared to a 1 percent drop for broadcast and a 32 percent increase for pay cable, according to FX research.Volume doesn’t guarantee quality, no matter what Netflix’s message may be, Landgraf said in a Q&A with critics that was part of FX’s promotion of upcoming and returning series, including “Better Things” and “Legion.””The flip side of taking hundreds of at-bats is you’re going to get a massive number of strikeouts. So naturally, Netflix made and launched a number of consumer failures,” he said. “But by reporting singles as if they were home runs, and failing to ever report a single strikeout, they undercut” their claims.An outlet’s performance can only be verified by agreed-upon, consistent measurements such as those compiled and analyzed by Nielsen, he said, noting the company is measuring Netflix and is adding Hulu and Amazon this year. While some ratings for top-rated broadcast and cable shows are released publicly with network agreement, Nielsen has yet to do the same for Netflix.”One way or another, the truth will ultimately come out, as it always does,” said Landgraf, who maintained his customary even, somewhat professorial tone throughout his Netflix dissection. He called on critics to resist reporting what he called “cherry-picked data” and to wait for third-party measurements.He also asked the room to consider the issue in the larger context of journalism and the forces that the digital industry that encompasses Netflix has unleashed.”It’s just not a good thing for society when one entity or one person gets to unilaterally make the rules or pronounce the truth,” he said. Explore further In this Aug. 3, 2018 file photo, John Landgraf, CEO, FX Networks and FX Productions, participates in the executive panel during the FX Television Critics Association Summer Press Tour in Beverly Hills, Calif. Landgraf said Monday, Feb. 4, 2019, that Netflix is using cloudy measurements to claim increasing dominance among viewers. (Photo by Willy Sanjuan/Invision/AP, File) John Landgraf, the FX Networks chief executive who has frequently pointed out the glut of scripted TV, said Netflix is using cloudy measurements to claim increasing dominance among viewers. It’s an approach he said reflects a worrisome Silicon Valley arrogance.Applying long-used industry standards to Netflix, “their true batting average would be viewed as unimpressive,” Landgraf said.The streaming service has upended the TV industry with a gusher of programming beyond that of any other outlet. This year, Netflix also realized its goal of earning a best-picture Oscar nomination, for the film “Roma.”But success doesn’t necessarily stem from an “endless money cannon,” as Landgraf described spending by what he called Silicon Valley’s “monopolistic titans.”Netflix’s claim that 40 million households globally watched the series “You” is suspect, Landgraf said, contending the U.S figure would be only 8 million viewers if the industry’s average-viewership standard was applied. The streaming service generally refuses to release viewership numbers, emphasizing the subscriber growth it now pegs at more than 130 million worldwide, with nearly 60 million of those in the United States.”By creating a myth that they have used data to find the magic bullet of guaranteed commercial success that has eluded everyone else since the creation of television, they have given the impression that the vast majority of shows on their platform is working … and that they have or will soon have many more hits than anyone else,” Landgraf said.Netflix declined comment Monday. The company said in an earnings letter it counts a viewer if they “substantially complete at least one episode.”Landgraf, who dismissed that measure as meaningless, said a program like “Stranger Things” is rightly cited by Netflix as an audience “home run” but called it an outlier.FX is coming off a good year, with a wealth of Emmy and other awards for shows including “The Americans” and “The Assassination of Gianni Versace: American Crime Story.” Landgraf said he’s optimistic about FX’s future as Walt Disney Co. prepares to acquire 21st Century Fox, parent company of the channel. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2019 The Associated Press. All rights reserved.
COMMENTS COMMENT Published on The 15th Finance Commission, headed by NK Singh, on Wednesday commenced discussions with the Tamil Nadu government, political parties, major stakeholders in the State on various issues, including the environment.The 18-member delegation interacted with leaders of all major political parties in the State and representatives of the local governments. It also had discussions with leading economists and domain experts of Chennai and the region, Singh told reporters. “We were greatly enriched by the interactions and discussions with domain experts and economists…”Some of the suggestions that came up during the meeting with the economists included the variables to be taken into account while estimating nominal GDP; assumptions with regard to inflation and real GDP growth; the risks and challenges that lie ahead in making projections for 2020-2025, which is the tenure of the commission, he said.Further, there were suggestions on tackling global warming and its effects on the environment, and on measures to prevent coastal erosions. In the evening, the delegation dined with Tamil Nadu Chief Minister Edapaddi K Palaniswami.On Thursday, the commission will hold a detailed discussion with the State government, before heading to Madurai. On Friday, as part of a field visit, the delegation will visit the 640 MW solar power plant at Kumudhi, India’s largest, and, en route to Rameshwaram, visit performance-based maintenance contract roads in Ramanathapuram district, said State government sources. Holds discussions on variables to compute GDP, check ecological destruction September 05, 2018 SHARE SHARE EMAIL economy (general) SHARE
Published on COMMENT The Central Government has appointed Larsen & Toubro (L&T) Group Chairman A M Naik as the chairman of the National Skill Development Corporation (NSDC).Skill Development and Entrepreneurship Minister Dharmendra Pradhan said under Naik’s leadership, the corporation apart from its engagement in executing skilling modules, should also be a think-tank providing direction and necessary guidance for creating a demand-based skilling ecosystem in the country.Naik commented that the NSDC has developed a unique model combining skill development with strong industry partnerships.NSDC, under the ministry, aims to promote skill development by catalysing creation of large, quality and for-profit vocational institutions.The organisation provides funding to build scalable and profitable vocational training initiatives. AM Naik. File photo NSDC aims to promote skill development by catalysing creation of large, quality and for-profit vocational institutions. SHARE SHARE EMAIL L&T Group November 28, 2018 NSDC SHARE COMMENTS
Press Trust of India New DelhiJuly 12, 2019UPDATED: July 12, 2019 13:05 IST During the debate, the Opposition accused the Modi government of trying to sell off railways’ assets instead of focusing on services. (File Photo)The Lok Sabha sat till 11.58 pm on Thursday to conclude discussion on demands for grants for the Railway Ministry, with Parliamentary Affairs Minister Prahlad Joshi saying it is for the first time in nearly 18 years that the Lower House has sat for this long.Railway Minister Piyush Goyal is likely to reply to the debate Friday afternoon, following which the demands for grants will be put to vote.Nearly a 100 members participated in the debate which began Thursday afternoon and concluded at 11.58 pm.”It is a record,” Joshi said.During the debate, the Opposition accused the Modi government of trying to sell off railways’ assets instead of focusing on services, but the BJP asserted that the transport behemoth is breaking new ground everyday especially in areas of infrastructure and safety.The Congress, TMC and other parties tore into the government as they opposed alleged attempts to “privatise” the railways and claimed that the NDA dispensation was “selling dreams” like the ‘bullet train’ to the people, which were “not feasible”.Countering the opposition’s allegations, BJP MP Sunil Kumar Singh said the performance of railways is much better now than under the Congress rule and the national transporter was achieving new milestones.Railway accidents have reduced by 73 per cent in the five-year period of Modi government from 2014 to 2019, he noted.ALSO READ | 29 elected unopposed to Parliamentary Estimates panelALSO WATCH | Narendra Modi arrives for the first parliament session of 17th Lok SabhaFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySnigdha Choudhury Next With 100 members in attendance, Lok Sabha sits till 11.58 pm to conclude debate on railwaysParliamentary Affairs Minister Prahlad Joshi said it is for the first time in nearly 18 years that the Lower House has sat for this long.advertisement
Siddaramaiah exudes confidence of winning trust vote, says it’s a joint decisionSenior Congress leader Siddaramaiah on Friday said the decision to seek a trust vote by the coalition government headed by Chief Minister HD Kumaraswamy was taken by the two ruling partners and asserted it has the numbers.advertisement Next Press Trust of India BengaluruJuly 12, 2019UPDATED: July 12, 2019 20:00 IST Replying to questions, Siddaramaiah said without numbers or confidence none will seek a trust vote. (Photo: PTI)Senior Congress leader Siddaramaiah on Friday said the decision to seek a trust vote by the coalition government headed by Chief Minister HD Kumaraswamy was taken by the two ruling partners and asserted it has the numbers.The Congress Legislature Party Leader also said he had been talking to disgruntled party MLAs barring Roshan Baig because he has been suspended.”Yesterday, we took the decision (on the trust vote) after discussions,” the former chief minister told reporters.Kumaraswamy, whose government is teetering on the brink of collapse after 16 MLAs of the ruling combine resigned, made the announcement about trust vote in the assembly earlier on Friday.Replying to questions, Siddaramaiah said without numbers or confidence none will seek a trust vote.”We have confidence, so we are moving the confidence motion,” he added.On how the ruling combine would muster the numbers, Siddaramaiah said, How can we disclose now? You will come to know when the vote of confidence is moved. Things like how it will happen, who will be present cannot be disclosed now.”To a question, he ruled out the possibility of a counter-operation to the alleged toppling bid of BJP, saying his party did not belive in operations.He refused to comment on the Supreme Court ordering status quo in the matter of resignation and disqualification of ten rebel MLAs.However, he added the Speaker was empowered under the anti-defection law to decide on disqualification of MLAs.Also Read | Karnataka crisis: Will face all issues on floor of House, says CM KumaraswamyAlso Read | Karnataka crisis: No decision on rebel MLAs till July 16, SC tells SpeakerAlso Watch | Kumaraswamy seeks floor test, says he govt has numbersFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byShifa Naseer Tags :Follow KumaraswamyFollow Karnataka crisisFollow Siddaramaiah