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19 days agoChelsea winger Christian Pulisic eyeing loan move away

first_imgChelsea winger Christian Pulisic eyeing loan move awayby Paul Vegas19 days agoSend to a friendShare the loveChelsea winger Christian Pulisic is eyeing a loan move away in January.The Daily Mailsays he is said to be considering asking for a loan move away from Chelsea if he is not given more opportunities soon.Pulisic has found himself falling down the pecking order at Stamford Bridge just three months after completing his £58million move from Borussia Dortmund.The 21-year-old has been an unused sub in the last three Premier League matches – and hasn’t been seen in top flight action since August.Now the American is open to the prospect of moving elsewhere in January if Frank Lampard continues to overlook him in his Chelsea plans. TagsTransfersAbout the authorPaul VegasShare the loveHave your saylast_img read more

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Clean energy producers can move NCLT against discoms over dues

first_imgNew Delhi: Flagging non-payment of dues by power discoms to renewable energy producers, Union Power Minister R K Singh has cautioned seven states, including Maharashtra and Karnataka, that the developers could approach NCLT against the distribution companies to recover payments of around Rs 5,355 crore. Singh in a letter has urged the chief ministers of these states to issue directions to their respective power distribution companies (discoms) for clearing the dues of renewable energy firms in the next few days. Also Read – Thermal coal import may surpass 200 MT this fiscalThe power and new & renewable energy minister pointed out the power producers are likely to default on their payment obligations due to non-clearance of dues by the discoms and there is a “danger” of them approaching the National Company Law Tribunal (NCLT) for recovering the pending amount. “Due to the non-payment of dues, it is likely that many of these RE (renewable energy) power producers would default in making payment to Ireda (Indian Renewable Energy Development Agency) and other financial institutions. Any default would make them NPAs (non-performing assets),” the Union minister said.last_img read more

Scientists create comprehensive new method to predict breast cancer risk

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Jan 14 2019Scientists have created the most comprehensive method yet to predict a woman’s risk of breast cancer, according to a study by Cancer Research UK published in Genetics in Medicine.They have a developed a way of calculating the risk of developing the disease by combining information on family history and genetics with other factors such as weight, age at menopause, alcohol consumption and use of hormone replacement therapy.Although individually some of these things have a small impact on the likelihood of developing the disease, researchers found that by considering all of them at once, plus family history and genetics, they can identify groups of women who have different risks of developing breast cancer.Importantly, for the first time, researchers have taken into account more than 300 genetic indicators for breast cancer. This makes calculating the risk much more precise than ever before.From this, the researchers have created an online calculator for GPs to use in their surgeries. Some GPs, practice nurses and genetic counselors are testing this tool before it is considered for wider use. Doctors are prompted to answer a series of online questions about their patient including their medical and family history, whether they have any known genetic alterations linked to cancer, their weight and whether they drink alcohol.In the future, information like this could help to tailor breast cancer screening depending on an individual’s risk. For example, it could help determine what age they are first invited for breast screening or how regularly they are invited to receive it.The risk calculation could also help people to make decisions about preventative therapy – such as identifying women at high risk who may benefit from taking the drug tamoxifen – as well as encouraging women to think about the ways they could reduce the risk themselves, for example trying to keep a healthy weight.Related StoriesSugary drinks linked to cancer finds studyNew study to ease plight of patients with advanced cancerTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerProfessor Antonis Antoniou, lead author at the University of Cambridge, said: “This is the first time that anyone has combined so many elements into one breast cancer prediction tool. It could be a game changer for breast cancer because now we can identify large numbers of women with different levels of risk – not just women who are at high risk.”This should help doctors to tailor the care they provide depending on their patients’ level of risk. For example, some women may need additional appointments with their doctor to discuss screening or prevention options and others may just need advice on their lifestyle and diet. “We hope this means more people can be diagnosed early and survive their disease for longer, but more research and trials are needed before we will fully understand how this could be used.”Breast cancer is the most common cancer in the UK. Nearly 55,000 women are diagnosed with the disease each year. But a large proportion of breast cancer cases occur in people who are at an increased risk. Cancer Research UK has helped to double breast cancer survival over the last 40 years.Dr Richard Roope, Cancer Research UK’s GP expert, said: “Research like this is hugely exciting because in the future it will enable us to offer much more tailored care which will benefit patients and make best use of the services that we have available.”Although having an increased risk of breast cancer means a woman is more likely to develop the disease – it’s by no means a certainty. A woman at high risk may never get breast cancer just as a woman at low risk still could. But any woman with concerns should speak to her GP to discuss the options.”Source: https://www.cancerresearchuk.org/about-us/cancer-news/press-release/2019-01-15-researchers-develop-comprehensive-new-way-to-predict-breast-cancer-risklast_img read more

UQ research may explain why vitamin D is essential for brain health

first_img Source:https://www.uq.edu.au/news/article/2019/02/potential-link-between-vitamin-d-deficiency-and-loss-of-brain-plasticity Reviewed by Alina Shrourou, B.Sc. (Editor)Feb 20 2019University of Queensland research may explain why vitamin D is vital for brain health, and how deficiency leads to disorders including depression and schizophrenia.Associate Professor Thomas Burne at UQ’s Queensland Brain Institute led the studies, which provide the groundwork for research into better prevention and treatments.”Over a billion people worldwide are affected by vitamin D deficiency, and there is a well-established link between vitamin D deficiency and impaired cognition,” Dr Burne said.”Unfortunately, exactly how vitamin D influences brain structure and function is not well understood, so it has remained unclear why deficiency causes problems.”Dr Burne’s team found that vitamin D levels affect a type of ‘scaffolding’ in the brain, called perineuronal nets.Related StoriesPosterior parietal cortex plays crucial role in making decisions, research showsNeural pathways explain the relationship between imagination and willingness to helpNew therapy shows promise in preventing brain damage after traumatic brain injury”These nets form a strong, supportive mesh around certain neurons, and in doing so they stabilise the contacts these cells make with other neurons,” he said.Researchers removed vitamin D from the diet of a group of healthy adult mice, and after 20 weeks found a significant decline in their ability to remember and learn compared to a control group.Dr Burne said the vitamin D deficient group had a pronounced reduction in perineuronal nets in the hippocampus, the brain region crucial to memory formation.”There was also a stark reduction in both the number and strength of connections between neurons in that region.”Dr Burne’s team propose that vitamin D plays an important role in keeping perineuronal nets stable, and that when vitamin D levels drop, this ‘scaffolding’ is more easily degraded by enzymes.”As neurons in the hippocampus lose their supportive perineuronal nets, they have trouble maintaining connections, and this ultimately leads to a loss of cognitive function.”Associate Professor Burne said the hippocampus may be most strongly affected by vitamin D deficiency because it is much more active than other brain regions.”It’s like the canary in the coalmine–it might fail first because its high energy requirement makes it more sensitive to the depletion of essential nutrients like vitamin D.”Intriguingly, the right side of the hippocampus was more affected by vitamin D deficiency than the left side.”Associate Professor Burne said loss of function in this area could be an important contributor to the hallmarks of schizophrenia, including severe memory deficits and a distorted perception of reality.”The next step is to test this new hypothesis on the link between vitamin D deficiency, perineuronal nets and cognition,” he said.”We are also particularly excited to have discovered these nets can change in adult mice.”I’m hoping that because they’re dynamic there is a chance that we can rebuild them, and that could set the stage for new treatments.”last_img read more

Mothers with children taken into outofhome care more likely to receive inadequate

first_img Source:http://www.cmaj.ca/ Reviewed by James Ives, M.Psych. (Editor)Feb 25 2019Mothers whose first child was taken into care were found to have inadequate or no prenatal care during subsequent pregnancies, according to a study published in CMAJ (Canadian Medical Association Journal) https://bit.ly/2In4aS7.The study was conducted in the province of Manitoba, which has one of the highest rates of children in out-of-home care in developed countries. About 3% of children live in homes without parental caregivers compared with a rate of 1% of children in most developed countries.A total of 52 438 mothers were included in the study, of whom 1284 (2.4%) had their first child placed in out-of-home care before conceiving a second child. These mothers were more likely to have a substance use disorder, live in low-income and urban neighborhoods, receive income assistance and have diabetes. They were also 46% more likely to receive inadequate prenatal care than women whose children had not been taken into care.”Previous research has identified a fear of detection or involvement with child protection services as an important barrier for at-risk pregnant women, potentially leading to disengagement from, avoidance of or delayed presentation to prenatal care,” writes Dr. Elizabeth Wall-Wieler, Department of Pediatrics, Stanford University, Palo Alto, California, with coauthors. “We expect this fear to be intensified for pregnant women who had their first child taken into care by child protection services because they may fear this happening again.”A harm reduction approach that provides easily accessible and nonjudgmental prenatal care could increase access to care for these women.”Pregnancy presents an important opportunity to increase positive outcomes for vulnerable women and to enable children to have the best possible start in life,” write the authors. “This represents an obligation within the child rights principles and a crucial strategy for reducing population-level health disparities.”Related StoriesGuidelines to help children develop healthy habits early in lifeWhy Mattresses Could be a Health Threat to Sleeping ChildrenNew therapeutic food boosts key growth-promoting gut microbes in malnourished childrenIn a related commentary http://www.cmaj.ca/lookup/doi/10.1503/cmaj.190183, Indigenous maternal-child health experts Dr. Janet Smylie and Wanda Phillips-Beck state that the exposed cohort in the linked study “was very likely to be largely Indigenous.” They describe the barriers that First Nations, Inuit and Métis women face in accessing prenatal care, which Dr. Smylie saw while providing obstetric care in an urban clinic in the late 1990s. “These barriers included but went beyond the basic material needs such as transportation and the need to prioritize housing, food security and safe child care over scheduled medical appointments. Women feared being misunderstood and incorrectly judged by culturally biased maternity care providers who, without reflection on how social stereotyping was driving their clinical interactions and decision-making, would deem them inadequate mothers-to-be and contact child protection agencies.”The authors state that this situation is a consequence of colonialism. “These processes are also acknowledged to be ongoing, contributing to a situation where there are now more Indigenous children in Canada’s child welfare system than when residential schools were at their peak.”To move past this, there must be support for Indigenous-led community solutions with First Nations, Inuit and Métis actively involved in the research and system transformation.last_img read more

Low levels of certain eye proteins could serve as predictor for Alzheimers

first_imgBy Sally Robertson, B.Sc.Mar 19 2019Researchers at Boston Medical Center have found that low eye-fluid levels of two proteins associated with Alzheimer’s could serve as a potential predictor of the disease. Shutterstock | Kuttelvaserova StuchelovaThe study showed that low levels of amyloid-β and tau proteins in the eye was significantly associated with poor cognitive scores.Alzheimer’s disease is characterized by abnormal levels of amyloid- β and tau, with amyloid proteins forming deposits in the brain many years before symptoms arise. Diagnosing and treating Alzheimer’s disease in the early stages, before symptoms present, significantly improves the chances of therapy being effective.Related StoriesEye research charity funds development of ‘organ-on-a-chip’ to fight glaucomaAmerican Academy of Ophthalmology shares tips for staying safe around fireworks’Eye-in-a-dish’ model helps scientists to uncover ‘surprising’ AMD gene variantThe study, which is the first to link ocular levels of the biomarkers with mental status, suggests that an eye test for the proteins could be a cost-effective, convenient way of predicting future Alzheimer’s risk.Studies have already shown that low levels of amyloid-β and tau in the cerebrospinal fluid (CSF) is associated with preclinical disease – where the pathological brain changes have started, but clinical symptoms have not yet developed. However, the lumbar puncture or “spinal tap” procedure that is used to obtain CSF is expensive and often inconvenient for patients to undergo.Now, ophthalmologist Lauren Wright and colleagues have tested eye fluid extracted from 80 patients who had previously undergone eye surgery. After determining the level of amyloid-β and tau in the samples, the team found that lower levels of the biomarkers were associated with lower scores on a baseline cognitive test the patients had taken.Furthermore, the cognitive test scores showed that some of the participants with low levels of the proteins already showed signs of mild-to-moderate dementia.”These findings could help us build an accessible, and minimally invasive test to determine Alzheimer’s disease risk, especially among patients with eye disease,” says Wright.The findings support previous research indicating that patients with eye disease may be at risk for Alzheimer’s disease. They also suggest that further studies of these patients may generate results that can be applied to the broader population.Senior author Manju Subramanian says the research represents a great step in establishing the important role the eye could in play diagnosing preclinical Alzheimer’s.“Further study is needed comparing protein biomarkers in the eye with more in-depth neurological testing,” he concludes. Source:https://www.eurekalert.org/pub_releases/2019-03/bmc-sft031819.phplast_img read more

New biomaterial could encapsulate and protect implanted insulinproducing cells

first_imgUsing stem cellsThe project hopes to solve another barrier to cell-transplantation treatment, which is the need for large amounts of pancreatic cells from deceased donors. It has been using human stem cells that are driven to become insulin-producing cells.Researchers studied both encapsulated pancreatic islets and encapsulated human induced pluripotent stem cells to determine their behavior and functionality after implantation in preclinical models. These preclinical studies are also being finalized.The project’s multidisciplinary approach draws on synthetic biology, nanobiotechnology and molecular and cellular biology.The smart, bioengineered materials to be used in the ELASTISLET capsules are named elastin-like recombinamers and have not been tried before to treat diabetes. They are inspired by a natural protein, elastin, that is found in the body’s connective tissue. It can be manipulated to have multifaceted chemical, physical and biological properties.Related StoriesTAU’s new Translational Medical Research Center acquires MILabs’ VECTor PET/SPECT/CTObese patients with Type 1 diabetes could safely receive robotic pancreas transplantOlympus Europe and Cytosurge join hands to accelerate drug development, single cell researchThese advantages allow the capsules to mimic the natural tissue environment to ensure they do not provoke an immune response. The capsules are designed to allow the recipient’s blood vessels to grow on to them – but not into them, which would trigger an immune response.Other applications‘The smart biomaterials at the core of our therapeutic solutions have been emerging with extraordinary strength, not only in the field of cell therapy, but also in many different areas of biomedicine, such as regenerative medicine, tissue engineering and drug delivery,’ says Rodríguez-Cabello. ‘Our efforts thus contribute to provide further evidence of their versatility and extraordinary potential to impact on other diseases and conditions.’Type 1 diabetes leads to increased risk of developing an array of life-threatening problems, in the long term. Incorrect levels of glucose can result in damage to a variety of tissues and organs, in particular blood vessels, the heart and kidneys, the eyes and nerves.According to the project, the number of people with diabetes in Europe is expected to reach 38 million by 2030, increasing the financial burden on the health care system. Recent studies found that the overall cost of diabetes is estimated to exceed EUR 188 billion in the UK, Spain, Italy, France and Germany. A cost-effective solution such as the one the project is offering could help significantly reduce this.The project developed a maze game – Discover the Isle of Elastislet – as a part of a range of communication materials to spread the message about the disease and encourage learning while playing. The game is an educational project designed to reach teachers, pupils, parents and children with diabetes as well as the general public. Players answer simple questions about diabetes, while trying not to get lost, as they discover how the research is addressing cell transplantation treatments for the disease. Source:European Commission This project represents the preclinical phase of developing this bioengineered solution and we have been working on the bioproduction, chemical modification and characterization of the smart materials at the core of our encapsulation strategy. The project is in the process of finalizing these preclinical studies. Building on the success of this phase, we will soon be ready to start first-in-man clinical studies in type 1 diabetes patients.”José Carlos Rodríguez-Cabello, Project Coordinator, University of Valladolid, Spain Reviewed by Alina Shrourou, B.Sc. (Editor)Jul 4 2019Transplanting insulin-producing pancreatic cells into people with type 1 diabetes has emerged as a ground-breaking treatment for millions of patients over the past few decades. However, one of the barriers to its effectiveness is the body’s natural auto-immune response, which results in the death of the implanted cells.In response, the EU-funded ELASTISLET project developed a semi-permeable and biocompatible material to encapsulate and protect the implanted cells from immune attack while it is being integrated into the patient’s body.While impermeable to immune cells, antibodies and other unwanted visitors, the bio-coating allows oxygen, nutrients and glucose into the protective capsule, and insulin to enter the bloodstream.last_img read more

Increased costs bit US retailers despite higher holiday sales

first_imgSales were dented by a fire in a distribution center in West Virginia and a pre-Christmas “earn and redeem” promotional event that was unsuccessful, Macy’s said.”The holiday season began strong,” Macy’s Chief Executive Jeff Gennette said, “but weakened in the mid-December period and did not return to expected patterns until the week of Christmas.”Target said comparable sales grew 5.7 percent over the holiday, while Kohl’s put sales growth at 1.2 percent. L Brands, the parent of Victoria’s Secret, reported flat comparable sales for the five weeks ending January 5.Bookseller Barnes & Noble estimated sales growth at 1.3 percent over the two-month period, adding that its earnings guidance “may be reduced by as much as 10 percent” due to increased advertising and promotional costs.Shares of Target fell 4.0 percent, Kohl’s dropped 7.1 percent, L Brands 7.6 percent and Barnes & Noble plunged 13.0 percent.Analysts said the declines were exacerbated by expectations that earnings growth will be tough in 2019 after a strong 2018 following the US tax cut enacted in late 2017.An exception was Bed Bath & Beyond, which surged 13.5 percent after it projected flat earnings in 2019 instead of the decline that had been previously seen. The company expects investments in store beautification, e-commerce software upgrades and other ventures to pay off more.The company raised its threshold for offering free shipping to $39 from $29 and required a threshold for delivery of $19 over the Thanksgiving weekend instead of nothing.”You’ll have certain customers perhaps not buy due to the higher threshold and perhaps other customers add something to the cart,” said Chief Executive Steven Temares.”It does have some impact on sales, but it’s difficult to quantify.” Holiday shopping reports released Thursday underscored anew the challenges US retailers face in the Amazon era—even if consumers are willing to open their wallets to spend. The updates were a mixed bag overall, with several retailers reporting small or moderate increases in comparable store sales during the critical November-December period.But a report from Macy’s aroused the most angst on Wall Street, after the chain slashed its profit forecast even as it signaled a modest increase in sales.Shares in Macy’s plunged almost 20 percent, while nearly every major retailer was pulled down as well.That included companies like Target that reported higher holiday sales and confirmed—but did not raise—profit forecasts.The results were an ugly finale to a holiday shopping season that opened with high expectations owing to robust consumer confidence amid a strong employment market, relatively low gasoline prices and a boost from tax cuts.Mastercard SpendingPulse in December estimated holiday sales growth of around 5.1 percent to more than $850 billion, the strongest jump in the last six years.By that estimate, the 2018 holiday shopping season was a strong one—just not for retailers.”It was a good season. Consumers had more money to spend. They spent it,” said retail industry consultant Dana Telsey. “But the cost of doing business is getting higher.” Citation: Increased costs bit US retailers despite higher holiday sales (2019, January 11) retrieved 17 July 2019 from https://phys.org/news/2019-01-bit-retailers-higher-holiday-sales.html Bed Bath & Beyond shares surged 13.5 percent after it projected flat earnings in 2019 instead of the decline that had been previously seen Macy’s had higher sales over the holidays, but still had to trim its profit forecast because of higher costs. Explore further Eating costsTraditional brick-and-mortar retailers have invested in heavily beefing up their online platforms and offering incentives to lure buyers, such as free shipping during the peak holiday season.At the same time, these companies also have spent heavily to improve the in-store experience, hiring consultants to help beautify the surroundings and in many cases employing more workers during the peak festive season.The latest results suggested retailers still have not found a winning recipe for the transition to the e-commerce era.”We know expenses are always a problem as more and more stuff moves online because people simply will not pay for you shipping it to them,” said retail industry consultant Jan Rogers Kniffen.”They want it to be the same price in the store in my door. That’s just the way it is.”Experts say the retail industry is still undergoing an existential shakeout. Retailers ate more of the promotion costs over the holiday season, denting the profit boost despite a strong consumer environment. Target plays to strength, combining digital sales and stores This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2019 AFP Companies like Macy’s, JC Penney and Gap have shuttered stores in recent years, while Toys “R” Us went out of business—a fate that could soon befall iconic American retailer Sears.Wall Street seeing redMacy’s shares tumbled 18.7 percent after it reported an increase of 1.1 percent in comparable sales, but lowered its annual earnings forecast to a range of $3.95 to $4.00 a share from $4.10 to $4.30.last_img read more

MH17 nextofkin say Msias stand on investigation confusing demand briefing

first_img Nation 09 Jul 2019 Dr M: No one to lead Malaysia Airlines yet Airlines 15 Jun 2019 Investigators to identify Malaysia Airline MH17 suspects Related News KUALA LUMPUR: The next-of-kin (NOK) of 31 victims of Malaysia Airlines (MAS) flight MH17 has urged local authorities to brief them over its action plans over the mystery of the ill-fated plane which went down in 2014.In a statement, NOK said the inaction by local authorities has caused distress and discontent.According to the group, Malaysia Airlines and Khazanah Nasional Bhd had not released any statements over the MH17 investigation.”We would therefore like to be briefed by the relevant Malaysian authorities on the action plans in place, if any, which are aimed to uncover the truth behind the incident which had taken the lives of 41 Malaysian citizens. AdChoices广告NOK also criticised contradicting statements made by the government against the Joint Investigation Team (JIT).”These statements have added confusion and caused anguish to some of the NOK,” it added.Last June, the JIT, consisting of Australia, Belgium, Malaysia, the Netherlands and Ukraine, announced that four individuals – three Russians and one Ukrainian – would be charged with the downing of MH17.According to the NOK, Malaysia’s representative on the JIT, Mohamed Hanafiah, said that Malaysia supported the JIT’s conclusions .”Notwithstanding, statements made by Malaysian officials subsequent to said press conference are inconsistent with the position taken by Mohamed Hanafiah.”To our knowledge, the JIT is the only body that has been working tirelessly for the last five years to uncover the truth behind the MH17 incident and to hold accountable those responsible for the tragedy.”In the absence of any other investigations or findings, we would like to express our full support to the JIT and the findings which have since been presented.”We would also like to place on record our sincere gratitude and appreciation for their efforts thus far.”On June 20, Prime Minister Tun Dr Mahathir Mohamad described the decision to charge the four individuals with murder over flight MH17 as a political plot against Russia.He said Malaysia was not convinced by the JIT’s findings and demanded that the investigators provide proof that the Russians were behind the shooting.The four were Russian nationals Igor Girkin, Sergey Dubinskiy and Oleg Pulatov, and Ukrainian Leonid Kharchenko.Related stories:Wisma Putra: Work with JIT to bring justice for MH17Pompeo ups MH17 pressurePM: Blaming Russia for MH17 is politically motivatedMalaysia Airlines others avoid parts of Iran-controlled airspaceCharging Individuals on the basis of a deeply flawed investigationResuscitating Malaysia Airlines now is a tough call: JomoMH17 probe still an ongoing process, says Saifuddin World 19 Jun 2019 Russians, Ukrainian to face murder charges over downing of Flight MH17 Related News {{category}} {{time}} {{title}}last_img read more